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Grn - granulin Gene

Also Known as GP88; PEPI; Pgrn; PCDGF; epithelin

Species: Mus musculus

Gene Type: protein coding

Gene ID: 14824

Summary

Predicted to enable chaperone binding activity. Involved in several processes, including astrocyte activation involved in immune response; positive regulation of cellular component organization; and regulation of defense response. Acts upstream of or within several processes, including blastocyst hatching; locomotory exploration behavior; and lysosomal protein catabolic process. Located in several cellular components, including endoplasmic reticulum; lysosome; and trans-Golgi network. Is expressed in several structures, including early conceptus; gonad; integument; nervous system; and placenta. Used to study Grn-related frontotemporal lobar degeneration with Tdp43 inclusions and nephrogenic diabetes insipidus. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); neuronal ceroid lipofuscinosis 11; and primary progressive multiple sclerosis. Orthologous to human GRN (granulin precursor). [provided by Alliance of Genome Resources, Apr 2022]

Grn Products (1)

mRNA	Protein	Name
NM_008175.5	NP_032201.3	progranulin precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12526812	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in astrocyte activation involved in immune response	IMP IMP: Inferred from mutant phenotype	20026663	MGI
acts upstream of or within blastocyst hatching	IDA IDA: Inferred from direct assay	15901638	MGI
acts upstream of or within embryo implantation	IDA IDA: Inferred from direct assay	15901638	MGI
acts upstream of epithelial cell proliferation	IDA IDA: Inferred from direct assay	15901638	MGI
acts upstream of or within locomotory exploration behavior	IMP IMP: Inferred from mutant phenotype	28728022	MGI
acts upstream of or within lysosomal protein catabolic process	IMP IMP: Inferred from mutant phenotype	28728022	MGI
involved in lysosomal transport	IMP IMP: Inferred from mutant phenotype	28541286	MGI
involved in lysosome organization	IMP IMP: Inferred from mutant phenotype	27789271	MGI
involved in maintenance of synapse structure	IDA IDA: Inferred from direct assay	29398357	MGI
involved in maintenance of synapse structure	IMP IMP: Inferred from mutant phenotype	29398357	MGI
involved in microglial cell activation involved in immune response	IMP IMP: Inferred from mutant phenotype	20026663	MGI
acts upstream of or within negative regulation of hydrolase activity	IMP IMP: Inferred from mutant phenotype	28728022	MGI
involved in negative regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	20026663	MGI
involved in negative regulation of innate immune response	IMP IMP: Inferred from mutant phenotype	20026663	MGI
involved in negative regulation of microglial cell activation	IMP IMP: Inferred from mutant phenotype	23041626	MGI
involved in positive regulation of angiogenesis	IDA IDA: Inferred from direct assay	12524533	MGI
involved in positive regulation of aspartic-type peptidase activity	IMP IMP: Inferred from mutant phenotype	28453791	MGI
involved in positive regulation of axon regeneration	IMP IMP: Inferred from mutant phenotype	28453791	MGI
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	12524533	MGI
involved in positive regulation of defense response to bacterium	IMP IMP: Inferred from mutant phenotype	20026663	MGI
involved in positive regulation of endothelial cell migration	IDA IDA: Inferred from direct assay	12524533	MGI
acts upstream of or within positive regulation of epithelial cell proliferation	IDA IDA: Inferred from direct assay	15901638	MGI
involved in positive regulation of inflammatory response to wounding	IDA IDA: Inferred from direct assay	12524533	MGI
involved in positive regulation of lysosome organization	IDA IDA: Inferred from direct assay	28073925	MGI
involved in positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	23041626	MGI
involved in positive regulation of protein folding	IMP IMP: Inferred from mutant phenotype	27789271	MGI
acts upstream of or within positive regulation of trophectodermal cell proliferation	IDA IDA: Inferred from direct assay	15901638	MGI
acts upstream of or within regulation of lysosome organization	IMP IMP: Inferred from mutant phenotype	28728022	MGI
acts upstream of or within retina development in camera-type eye	IMP IMP: Inferred from mutant phenotype	28728022	MGI
acts upstream of trophectodermal cell proliferation	IDA IDA: Inferred from direct assay	15901638	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	27789271	MGI
is active in cerebellar climbing fiber to Purkinje cell synapse	IDA IDA: Inferred from direct assay	29398357	MGI
is active in cerebellar climbing fiber to Purkinje cell synapse	IMP IMP: Inferred from mutant phenotype	29398357	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	27789271	MGI
located in extracellular region	IDA IDA: Inferred from direct assay	28073925	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	15901638	MGI
located in lysosome	IDA IDA: Inferred from direct assay	27789271	MGI
located in trans-Golgi network	IDA IDA: Inferred from direct assay	27789271	MGI
located in vesicle	IDA IDA: Inferred from direct assay	28453791	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
progranulin	PC cell-derived growth factor acrogranin acrogranulin epithelin/granulin glycoprotein 88 glycoprotein of 88 Kda granulins proepithelin

Recombinant Grn Proteins

Cat. No.	Product Name	Accession	Purity
HY-P78302	Progranulin/PGRN Protein, Mouse (HEK293, His)	P28798 (T18-L589)	≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12854	Imetelstat		99.43%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P4073	ANG1005		98.83%	Phase 3

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99688	Latozinemab	Inhibitor	96.03%	Phase 3

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-115733	Cathepsin L-IN-2	Inhibitor	98.02%	Unkown
HY-RS17678	Grn Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05843	GRN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-124393	GRN-529	Modulator	/	Unkown
HY-RS24139	Grn Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Grn	NCBI	NCBI:2896