Hand2 - heart and neural crest derivatives expressed 2 Gene

Also Known as Hed; Th2; dHAND; Ehand2; Thing2; bHLHa26

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15111

Summary

Enables protein homodimerization activity and sequence-specific DNA binding activity. Contributes to E-box binding activity. Involved in several processes, including heart morphogenesis; negative regulation of cardiac muscle cell apoptotic process; and positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis. Acts upstream of or within several processes, including animal organ development; negative regulation of osteoblast differentiation; and nervous system development. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; heart; and hindlimb phalanx. Orthologous to human HAND2 (heart and neural crest derivatives expressed 2). [provided by Alliance of Genome Resources, Apr 2022]

Hand2 Products (1)

mRNA Protein Name
NM_010402.4 NP_034532.3 heart- and neural crest derivatives-expressed protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
11812799 MGI
contributes to E-box binding IDA
IDA: Inferred from direct assay
11812799 MGI
enables E-box binding IDA
IDA: Inferred from direct assay
20144608 MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
11812799 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10924525 MGI
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
11812799 MGI
enables sequence-specific DNA binding IGI
IGI: Inferred from genetic interaction
12070084 MGI
contributes to transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
11812799 MGI
enables transcription factor binding IPI
IPI: Inferred from physical interaction
19144722 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within adult heart development IMP
IMP: Inferred from mutant phenotype
9171826 MGI
acts upstream of apoptotic process IMP
IMP: Inferred from mutant phenotype
19341725 MGI
acts upstream of or within apoptotic process involved in heart morphogenesis IMP
IMP: Inferred from mutant phenotype
11784028 MGI
involved in cardiac neural crest cell development involved in outflow tract morphogenesis IMP
IMP: Inferred from mutant phenotype
19008477 MGI
acts upstream of or within cardiac neural crest cell migration involved in outflow tract morphogenesis IMP
IMP: Inferred from mutant phenotype
20144608 MGI
involved in cardiac right ventricle formation IMP
IMP: Inferred from mutant phenotype
11076755 MGI
acts upstream of or within cartilage morphogenesis IGI
IGI: Inferred from genetic interaction
17764670 MGI
acts upstream of or within cell proliferation involved in outflow tract morphogenesis IMP
IMP: Inferred from mutant phenotype
20144608 MGI
acts upstream of or within coronary artery morphogenesis IMP
IMP: Inferred from mutant phenotype
21350214 MGI
acts upstream of or within determination of heart left/right asymmetry IMP
IMP: Inferred from mutant phenotype
9576835 MGI
acts upstream of or within embryonic digit morphogenesis IDA
IDA: Inferred from direct assay
12070084 MGI
involved in embryonic skeletal system development IGI
IGI: Inferred from genetic interaction
19017795 MGI
acts upstream of epithelial cell apoptotic process IMP
IMP: Inferred from mutant phenotype
19341725 MGI
acts upstream of or within heart development IGI
IGI: Inferred from genetic interaction
15576406 MGI
acts upstream of or within heart looping IMP
IMP: Inferred from mutant phenotype
9171826 MGI
acts upstream of or within heart morphogenesis IMP
IMP: Inferred from mutant phenotype
11784028 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
9171826 MGI
acts upstream of or within mesenchymal cell proliferation IMP
IMP: Inferred from mutant phenotype
19341725 MGI
acts upstream of or within mesenchyme development IGI
IGI: Inferred from genetic interaction
17764670 MGI
acts upstream of or within negative regulation of DNA binding IDA
IDA: Inferred from direct assay
19144722 MGI
acts upstream of or within negative regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
19144722 MGI
involved in negative regulation of cardiac muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
19008477 MGI
acts upstream of or within negative regulation of epithelial cell apoptotic process IMP
IMP: Inferred from mutant phenotype
19341725 MGI
acts upstream of or within negative regulation of osteoblast differentiation IDA
IDA: Inferred from direct assay
19144722 MGI
acts upstream of or within negative regulation of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
19144722 MGI
acts upstream of or within neural crest cell development IMP
IMP: Inferred from mutant phenotype
9671575 MGI
acts upstream of positive effect norepinephrine biosynthetic process IMP
IMP: Inferred from mutant phenotype
19008477 MGI
acts upstream of or within odontogenesis of dentin-containing tooth IGI
IGI: Inferred from genetic interaction
17764670 MGI
acts upstream of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
19144722 MGI
involved in outflow tract morphogenesis IMP
IMP: Inferred from mutant phenotype
19008477 MGI
acts upstream of or within peripheral nervous system neuron development IDA
IDA: Inferred from direct assay
16145670 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
16145670 MGI
acts upstream of or within positive regulation of DNA-templated transcription IGI
IGI: Inferred from genetic interaction
12070084 MGI
involved in positive regulation of semaphorin-plexin signaling pathway IMP
IMP: Inferred from mutant phenotype
19008477 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11812799 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
20144608 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
19008477 MGI
acts upstream of or within primary palate development IMP
IMP: Inferred from mutant phenotype
17531968 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15351717 MGI
involved in regulation of secondary heart field cardioblast proliferation IMP
IMP: Inferred from mutant phenotype
19008477 MGI
acts upstream of or within roof of mouth development IMP
IMP: Inferred from mutant phenotype
17531968 MGI
acts upstream of or within suckling behavior IMP
IMP: Inferred from mutant phenotype
17531968 MGI
acts upstream of or within sympathetic nervous system development IDA
IDA: Inferred from direct assay
16145670 MGI
involved in thymus development IMP
IMP: Inferred from mutant phenotype
19008477 MGI
acts upstream of or within tongue development IMP
IMP: Inferred from mutant phenotype
17531968 MGI
acts upstream of or within visceral serous pericardium development IMP
IMP: Inferred from mutant phenotype
21350214 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
19144722 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
11812799 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

heart- and neural crest derivatives-expressed protein 2

  • deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2

  • heart and neural crest derivatives expressed transcript 2

  • helix-loop-helix transcription factor expressed in embryo and deciduum

  • thing-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-177787A 2'-Deoxy-N-methyl-AMP ammonium / Unkown
HY-RS05997 HAND2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174480 Mouse Hand2 mRNA / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hand2 NCBI NCBI:9464