GDF7 - growth differentiation factor 7 Gene

Also Known as BMP12

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 151449

About GDF7

Cytogenetic location: 2p24.1 Genomic coordinates (GRCh38): 2:20,667,144-20,679,243 (from NCBI)

This gene has 1 transcript (splice variant), 212 orthologues and 31 paralogues. Biased expression in kidney (RPKM 1.0), endometrium (RPKM 0.6) and 7 other tissues.

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein may play a role in the differentiation of tendon cells and spinal cord interneurons. A mutation in this gene may be associated with increased risk for Barrett's esophagus and esophageal adenocarcinoma. [provided by RefSeq, Sep 2016]

GDF7 Products (1)

mRNA Protein Name
NM_182828.4 NP_878248.2 growth/differentiation factor 7 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16049014 GOA
Biological Process GO Annotation Evidence References Source
involved in BMP signaling pathway IDA
IDA: Inferred from direct assay
16049014 GOA
involved in activin receptor signaling pathway IDA
IDA: Inferred from direct assay
16049014 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
16049014 GOA
involved in positive regulation of SMAD protein signal transduction IDA
IDA: Inferred from direct assay
16049014 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GDF7 Protein Structure

TGFb_propeptide

TGFb_propeptide: TGF-beta propeptide (85 - 236)

TGF_beta

TGF_beta: Transforming growth factor beta like domain (347 - 450)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 450 a.a.
Protein Preferred Names Protein Names

growth/differentiation factor 7

  • GDF-7

Recombinant GDF7 Proteins

Cat. No. Product Name Accession Purity
HY-P700021AF Animal-Free BMP-12/GDF-7 Protein, Human (His) Q7Z4P5 (T322-R450) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Shoulder Impingement Syndrome

  • Impingement Syndrome Of Shoulder Region

  • Subacromial Impingement
Epicondylitis

  • Tennis Elbow

  • Lateral Epicondylitis

  • Golfer'S Elbow

  • Medial Epicondylitis

  • Andrel Epicondylitis

  • Archer'S Elbow

  • Hockey Elbow

  • Shooter'S Elbow
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05357 GDF7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19900 Gdf7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26401 Gdf7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GDF7 MGD MGI:95690
Macaca mulatta GDF7 VGNC VGNC:106167
Rattus norvegicus GDF7 RGD RGD:620105
Bos taurus GDF7 VGNC VGNC:29305
Others GDF7 NCBI