GDF7 - growth differentiation factor 7 Gene

Homo sapiens

Also known as BMP12

Gene ID: 151449 | Gene type: protein coding

About GDF7

Cytogenetic location: 2p24.1 Genomic coordinates (GRCh38): 2:20,667,144-20,679,243 (from NCBI)

This gene has 1 transcript (splice variant), 212 orthologues and 31 paralogues. Biased expression in kidney (RPKM 1.0), endometrium (RPKM 0.6) and 7 other tissues.

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein may play a role in the differentiation of tendon cells and spinal cord interneurons. A mutation in this gene may be associated with increased risk for Barrett's esophagus and esophageal adenocarcinoma. [provided by RefSeq, Sep 2016]

GDF7 Products(1)

mRNA	Protein	Name
NM_182828.4	NP_878248.2	growth/differentiation factor 7 preproprotein

GDF7 Protein Structure

TGFb_propeptide

TGF_beta

0
100
200
300
400
450 a.a.

Protein Preferred Names

Protein Names

growth/differentiation factor 7

GDF-7

Recombinant GDF7 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700021AF	Animal-Free BMP-12/GDF-7 Protein, Human (His)	Q7Z4P5 (T322-R450)	≥95%

Related Diseases

Diseases

Alias

Shoulder Impingement Syndrome

Impingement Syndrome Of Shoulder Region

Subacromial Impingement

Epicondylitis

Tennis Elbow	Lateral Epicondylitis
Golfer'S Elbow	Medial Epicondylitis
Andrel Epicondylitis	Archer'S Elbow
Hockey Elbow	Shooter'S Elbow

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05357	GDF7 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GDF7	MGD	MGI:95690
Macaca mulatta	GDF7	VGNC	VGNC:106167
Rattus norvegicus	GDF7	RGD	RGD:620105
Bos taurus	GDF7	VGNC	VGNC:29305