Hcn1 - hyperpolarization activated cyclic nucleotide gated potassium channel 1 Gene

Also Known as HAC2; Bcng1; C630013B14Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 15165

Summary

Enables cAMP binding activity; cation channel activity; and identical protein binding activity. Involved in cellular response to cAMP and potassium ion transmembrane transport. Acts upstream of or within apical protein localization and retinal cone cell development. Located in axon and dendrite. Is integral component of plasma membrane. Is expressed in brain; heart; and heart ventricle. Used to study sick sinus syndrome. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 24 and generalized epilepsy with febrile seizures plus 10. Orthologous to human HCN1 (hyperpolarization activated cyclic nucleotide gated Potassium Channel 1). [provided by Alliance of Genome Resources, Apr 2022]

Hcn1 Products (1)

mRNA	Protein	Name
NM_010408.3	NP_034538.2	potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cAMP binding	IDA IDA: Inferred from direct assay	22006928	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	22006928	MGI
enables intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential	EXP EXP: Inferred from Experiment	21358644	MGI
enables intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential	IDA IDA: Inferred from direct assay	21358644	MGI
enables intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential	IMP IMP: Inferred from mutant phenotype	21358644	MGI
enables intracellularly cAMP-activated cation channel activity	IDA IDA: Inferred from direct assay	30886335	MGI
enables intracellularly cAMP-activated cation channel activity	IMP IMP: Inferred from mutant phenotype	22006928	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15564593	MGI
enables voltage-gated potassium channel activity	IMP IMP: Inferred from mutant phenotype	22006928	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within apical protein localization	IMP IMP: Inferred from mutant phenotype	15564593	MGI
involved in cellular response to cAMP	IMP IMP: Inferred from mutant phenotype	22006928	MGI
acts upstream of or within general adaptation syndrome, behavioral process	IDA IDA: Inferred from direct assay	30886335	MGI
acts upstream of or within neuronal action potential	IDA IDA: Inferred from direct assay	30886335	MGI
involved in potassium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	22006928	MGI
involved in regulation of postsynaptic membrane potential	EXP EXP: Inferred from Experiment	18093528	MGI
involved in regulation of postsynaptic membrane potential	IDA IDA: Inferred from direct assay	18093528	MGI
involved in regulation of postsynaptic membrane potential	IMP IMP: Inferred from mutant phenotype	18093528	MGI
acts upstream of or within retinal cone cell development	IMP IMP: Inferred from mutant phenotype	21052544	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in axon	IDA IDA: Inferred from direct assay	15479642	MGI
located in dendrite	IDA IDA: Inferred from direct assay	15564593	MGI
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	18093528	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	18093528	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	18093528	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	30886335	MGI
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	22006928	MGI
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	21358644	MGI
is active in presynaptic active zone membrane	IDA IDA: Inferred from direct assay	21358644	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1	BCNG-1 HAC-2 brain cyclic nucleotide-gated channel 1 hyperpolarization-activated cation channel 2 hyperpolarization-activated, cyclic nucleotide-gated K+ 1

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-18940	Cilobradine		/	Phase 2
HY-W040555	Norquetiapine dihydrochloride		99.91%	Phase 1

Pre-clinical Phase

Bioactive Molecules (17)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-160505	RO-275	Inhibitor	99.95%	Unkown
HY-13422A	Zatebradine	Antagonist	99.27%	Unkown
HY-13422	Zatebradine hydrochloride	Antagonist	99.87%	Unkown
HY-W052508	Norquetiapine		99.95%	Unkown
HY-163455	pan-HCN-IN-1	Inhibitor	99.84%	Unkown
HY-108574	CP 339818 hydrochloride	Inhibitor	99.61%	Unkown
HY-W052508S	Norquetiapine-d8		/	Unkown
HY-114540	CP-339818	Inhibitor	/	Unkown
HY-182459	Org 34167 (freebase)	Modulator	/	Unkown
HY-186057	HCN2-IN-5	Inhibitor	/	Unkown
HY-186059	HCN2 modulator-4	Inhibitor	/	Unkown
HY-186059A	HCN2 modulator-5	Inhibitor	/	Unkown
HY-186060	HCN2 modulator-6	Inhibitor	/	Unkown
HY-186061A	HCN2 modulator-8	Inhibitor	/	Unkown
HY-RS06046	HCN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22198	Hcn1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28720	Hcn1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hcn1	NCBI	NCBI:348980