Hcrt - hypocretin Gene

Also Known as PPOX

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15171

Summary

This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors Hcrtr1 and Hcrtr2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. [provided by RefSeq, Sep 2015]

Hcrt Products (1)

mRNA Protein Name
NM_010410.2 NP_034540.1 hypocretin neuropeptide precursor precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
23700511 MGI
Cellular Component GO Annotation Evidence References Source
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
11748295 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hypocretin neuropeptide precursor

  • hypocretin neuropeptide

  • orexin A

  • orexin B

  • prepro-orexin

  • preprohypocretin

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-128850 N-Acetyl-D-mannosamine 99.99% Phase 2

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06050 HCRT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18943 Hcrt Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25433 Hcrt Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hcrt NCBI NCBI:3060