Herc2 - HECT and RLD domain containing E3 ubiquitin protein ligase 2 Gene

Also Known as rjs; jdf2; D15F32S1h; mKIAA0393; D7H15F32S1; D7H15F37S1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15204

Summary

Predicted to enable SUMO binding activity; ubiquitin protein Ligase activity; and ubiquitin protein Ligase binding activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Acts upstream of or within spermatogenesis. Located in mitochondrial inner membrane. Is expressed in several structures, including central nervous system; ganglia; and trunk. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability and pigmentation disease. Orthologous to human HERC2 (HECT and RLD domain containing E3 ubiquitin protein Ligase 2). [provided by Alliance of Genome Resources, Apr 2022]

Herc2 Products (2)

mRNA Protein Name
NM_001360080.1 NP_001347009.1 E3 ubiquitin-protein ligase HERC2
NM_010418.2 NP_034548.2 E3 ubiquitin-protein ligase HERC2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
26355680 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of Notch signaling pathway IDA
IDA: Inferred from direct assay
26355680 MGI
acts upstream of or within neuron differentiation IDA
IDA: Inferred from direct assay
26355680 MGI
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
26692333 MGI
acts upstream of or within spermatogenesis IMP
IMP: Inferred from mutant phenotype
5565073 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase HERC2

  • HECT domain and RCC1-like domain-containing protein 2

  • HECT-type E3 ubiquitin transferase HERC2

  • hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 2

  • probable E3 ubiquitin-protein ligase HERC2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06127 HERC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19689 Herc2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26183 Herc2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Herc2 NCBI NCBI:8924