Hes1 - hes family bHLH transcription factor 1 Gene

Also Known as Hry; bHLHb39

生物種: Mus musculus

遺伝子タイプ: protein coding
遺伝子ID: 15205

Summary

Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; HLH domain binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including circulatory system development; regulation of gliogenesis; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including animal organ development; negative regulation of cell differentiation; and nervous system development. Located in cytoplasm and nucleus. Part of protein-containing complex. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; foot bone; and sensory organ. Orthologous to human HES1 (hes family bHLH transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Hes1 Products (2)

mRNA Protein Name
NM_001413568.1 NP_001400497.1 transcription factor HES-1 isoform 2
NM_008235.3 NP_032261.1 transcription factor HES-1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables DNA binding IDA
IDA: Inferred from direct assay
10851137 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
15870295 MGI
enables DNA-binding transcription repressor activity IDA
IDA: Inferred from direct assay
17681138 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
21259317 MGI
enables E-box binding IDA
IDA: Inferred from direct assay
10851137 MGI
enables HLH domain binding IDA
IDA: Inferred from direct assay
17681138 MGI
enables N-box binding IDA
IDA: Inferred from direct assay
10851137 MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
10851137 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15156153 MGI
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
21259317 MGI
enables protein-folding chaperone binding IDA
IDA: Inferred from direct assay
16314515 MGI
Biological Process GO Annotation Evidence 参考文献 由来
acts upstream of BMP signaling pathway IGI
IGI: Inferred from genetic interaction
18579678 MGI
acts upstream of Cajal-Retzius cell differentiation IGI
IGI: Inferred from genetic interaction
18579678 MGI
acts upstream of or within Notch signaling pathway IDA
IDA: Inferred from direct assay
25535395 MGI
involved in S-shaped body morphogenesis IEP
IEP: Inferred from expression pattern
15821257 MGI
acts upstream of T cell proliferation IMP
IMP: Inferred from mutant phenotype
15870295 MGI
acts upstream of or within adenohypophysis development IMP
IMP: Inferred from mutant phenotype
18996108 MGI
acts upstream of amacrine cell differentiation IMP
IMP: Inferred from mutant phenotype
16038893 MGI
involved in aorta morphogenesis IMP
IMP: Inferred from mutant phenotype
20122914 MGI
involved in artery morphogenesis IMP
IMP: Inferred from mutant phenotype
20122914 MGI
involved in ascending aorta morphogenesis IMP
IMP: Inferred from mutant phenotype
19609448 MGI
acts upstream of or within cardiac neural crest cell development involved in outflow tract morphogenesis IMP
IMP: Inferred from mutant phenotype
19609448 MGI
acts upstream of or within cell adhesion IGI
IGI: Inferred from genetic interaction
15496443 MGI
acts upstream of or within cell fate commitment IMP
IMP: Inferred from mutant phenotype
10952889 MGI
acts upstream of cell fate determination IMP
IMP: Inferred from mutant phenotype
11425898 MGI
acts upstream of or within cell maturation IGI
IGI: Inferred from genetic interaction
15496443 MGI
acts upstream of or within cell migration IGI
IGI: Inferred from genetic interaction
18996108 MGI
acts upstream of or within cell morphogenesis involved in neuron differentiation IGI
IGI: Inferred from genetic interaction
11500373 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
16038893 MGI
acts upstream of or within cochlea development IGI
IGI: Inferred from genetic interaction
18302773 MGI
acts upstream of or within cochlea development IMP
IMP: Inferred from mutant phenotype
18302773 MGI
involved in comma-shaped body morphogenesis IEP
IEP: Inferred from expression pattern
15821257 MGI
acts upstream of or within common bile duct development IMP
IMP: Inferred from mutant phenotype
19619492 MGI
involved in embryonic heart tube morphogenesis IMP
IMP: Inferred from mutant phenotype
19609448 MGI
acts upstream of or within establishment of epithelial cell polarity IGI
IGI: Inferred from genetic interaction
21300049 MGI
involved in glomerulus vasculature development IEP
IEP: Inferred from expression pattern
15821257 MGI
acts upstream of or within hindbrain morphogenesis IGI
IGI: Inferred from genetic interaction
11500373 MGI
acts upstream of or within in utero embryonic development IGI
IGI: Inferred from genetic interaction
11500373 MGI
acts upstream of or within inhibition of neuroepithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
10952889 MGI
acts upstream of inner ear auditory receptor cell differentiation IGI
IGI: Inferred from genetic interaction
21300049 MGI
acts upstream of or within inner ear receptor cell stereocilium organization IGI
IGI: Inferred from genetic interaction
21300049 MGI
involved in labyrinthine layer blood vessel development IMP
IMP: Inferred from mutant phenotype
20122914 MGI
acts upstream of or within lateral inhibition IMP
IMP: Inferred from mutant phenotype
10804175 MGI
acts upstream of or within liver development IMP
IMP: Inferred from mutant phenotype
15578515 MGI
acts upstream of or within lung development IMP
IMP: Inferred from mutant phenotype
10952889 MGI
involved in metanephric nephron tubule morphogenesis IEP
IEP: Inferred from expression pattern
15465493 MGI
acts upstream of or within midbrain development IGI
IGI: Inferred from genetic interaction
11500373 MGI
acts upstream of or within midbrain-hindbrain boundary morphogenesis IGI
IGI: Inferred from genetic interaction
11500373 MGI
involved in negative regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
10851137 MGI
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
12208538 MGI
acts upstream of or within negative regulation of amacrine cell differentiation IMP
IMP: Inferred from mutant phenotype
16038893 MGI
acts upstream of or within negative regulation of cell differentiation IMP
IMP: Inferred from mutant phenotype
17426285 MGI
acts upstream of or within negative regulation of cell fate determination IMP
IMP: Inferred from mutant phenotype
11425898 MGI
involved in negative regulation of glial cell proliferation IDA
IDA: Inferred from direct assay
12666205 MGI
acts upstream of or within negative regulation of inner ear auditory receptor cell differentiation IGI
IGI: Inferred from genetic interaction
21300049 MGI
acts upstream of or within negative regulation of inner ear auditory receptor cell differentiation IMP
IMP: Inferred from mutant phenotype
11023859 MGI
involved in negative regulation of inner ear receptor cell differentiation IMP
IMP: Inferred from mutant phenotype
12208538 MGI
acts upstream of or within negative regulation of neuron differentiation IGI
IGI: Inferred from genetic interaction
10205173 MGI
acts upstream of or within negative regulation of neuron differentiation IMP
IMP: Inferred from mutant phenotype
10205173 MGI
involved in negative regulation of oligodendrocyte differentiation IDA
IDA: Inferred from direct assay
12666205 MGI
acts upstream of or within negative regulation of pancreatic A cell differentiation IMP
IMP: Inferred from mutant phenotype
10615124 MGI
acts upstream of or within negative regulation of stomach neuroendocrine cell differentiation IMP
IMP: Inferred from mutant phenotype
18173746 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11260262 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10851137 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
19050759 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
15870295 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
19609448 MGI
acts upstream of or within neural tube development IGI
IGI: Inferred from genetic interaction
10804175 MGI
acts upstream of neuroendocrine cell differentiation IMP
IMP: Inferred from mutant phenotype
10952889 MGI
acts upstream of neuron differentiation IGI
IGI: Inferred from genetic interaction
10205173 MGI
acts upstream of neuron differentiation IMP
IMP: Inferred from mutant phenotype
10205173 MGI
involved in neuronal stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
11399758 MGI
acts upstream of or within oculomotor nerve development IGI
IGI: Inferred from genetic interaction
11500373 MGI
acts upstream of or within outflow tract morphogenesis IMP
IMP: Inferred from mutant phenotype
19609448 MGI
involved in outflow tract morphogenesis IMP
IMP: Inferred from mutant phenotype
20122914 MGI
acts upstream of or within pancreas development IMP
IMP: Inferred from mutant phenotype
19619492 MGI
acts upstream of pancreatic A cell differentiation IMP
IMP: Inferred from mutant phenotype
10615124 MGI
acts upstream of or within pattern specification process IGI
IGI: Inferred from genetic interaction
18302773 MGI
acts upstream of or within pattern specification process IMP
IMP: Inferred from mutant phenotype
18302773 MGI
involved in pharyngeal arch artery morphogenesis IMP
IMP: Inferred from mutant phenotype
20122914 MGI
acts upstream of or within pituitary gland development IGI
IGI: Inferred from genetic interaction
17426285 MGI
acts upstream of or within pituitary gland development IMP
IMP: Inferred from mutant phenotype
17015435 MGI
acts upstream of or within positive regulation of BMP signaling pathway IGI
IGI: Inferred from genetic interaction
18579678 MGI
involved in positive regulation of DNA binding IDA
IDA: Inferred from direct assay
15156153 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
12208538 MGI
involved in positive regulation of Notch signaling pathway IMP
IMP: Inferred from mutant phenotype
12208538 MGI
acts upstream of or within positive regulation of T cell proliferation IMP
IMP: Inferred from mutant phenotype
15870295 MGI
involved in positive regulation of astrocyte differentiation IDA
IDA: Inferred from direct assay
12666205 MGI
acts upstream of or within positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
16038893 MGI
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
20122914 MGI
involved in positive regulation of mitotic cell cycle, embryonic IMP
IMP: Inferred from mutant phenotype
19609448 MGI
involved in positive regulation of receptor signaling pathway via JAK-STAT IDA
IDA: Inferred from direct assay
15156153 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
11500373 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
19609448 MGI
involved in positive regulation of tyrosine phosphorylation of STAT protein IDA
IDA: Inferred from direct assay
15156153 MGI
involved in protein-containing complex assembly IDA
IDA: Inferred from direct assay
15156153 MGI
acts upstream of or within regulation of epithelial cell proliferation IGI
IGI: Inferred from genetic interaction
21300049 MGI
acts upstream of or within regulation of fat cell differentiation IMP
IMP: Inferred from mutant phenotype
15060169 MGI
acts upstream of or within regulation of neurogenesis IGI
IGI: Inferred from genetic interaction
10804175 MGI
acts upstream of or within regulation of neuron differentiation IGI
IGI: Inferred from genetic interaction
10804175 MGI
involved in regulation of receptor signaling pathway via JAK-STAT IDA
IDA: Inferred from direct assay
15156153 MGI
acts upstream of or within regulation of secondary heart field cardioblast proliferation IMP
IMP: Inferred from mutant phenotype
19609448 MGI
acts upstream of or within regulation of timing of cell differentiation IMP
IMP: Inferred from mutant phenotype
8543157 MGI
acts upstream of or within regulation of timing of neuron differentiation IGI
IGI: Inferred from genetic interaction
11500373 MGI
acts upstream of or within regulation of timing of neuron differentiation IMP
IMP: Inferred from mutant phenotype
8543157 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
20628571 MGI
involved in renal interstitial fibroblast development IEP
IEP: Inferred from expression pattern
15821257 MGI
acts upstream of or within smoothened signaling pathway IDA
IDA: Inferred from direct assay
19124651 MGI
acts upstream of or within somatic stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
10615124 MGI
acts upstream of stomach neuroendocrine cell differentiation IMP
IMP: Inferred from mutant phenotype
18173746 MGI
acts upstream of or within telencephalon development IGI
IGI: Inferred from genetic interaction
18579678 MGI
acts upstream of or within telencephalon development IMP
IMP: Inferred from mutant phenotype
19050759 MGI
involved in thymus development IMP
IMP: Inferred from mutant phenotype
20122914 MGI
acts upstream of or within trochlear nerve development IGI
IGI: Inferred from genetic interaction
11500373 MGI
involved in ureteric bud morphogenesis IEP
IEP: Inferred from expression pattern
15821257 MGI
involved in vascular associated smooth muscle cell development IMP
IMP: Inferred from mutant phenotype
20122914 MGI
involved in ventricular septum development IMP
IMP: Inferred from mutant phenotype
20122914 MGI
involved in ventricular septum morphogenesis IMP
IMP: Inferred from mutant phenotype
19609448 MGI
Cellular Component GO Annotation Evidence 参考文献 由来
located in cytoplasm IDA
IDA: Inferred from direct assay
15645444 MGI
located in intracellular anatomical structure IDA
IDA: Inferred from direct assay
16489008 MGI
located in nucleus IDA
IDA: Inferred from direct assay
10952889 MGI
part of protein-containing complex IDA
IDA: Inferred from direct assay
17681138 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor HES-1

  • hairy and enhancer of split 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (12)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-19369 L-685458 99.69% Unkown
HY-117113 JI051 Inhibitor 98.0% Unkown
HY-107245 Segetalin B 99.56% Unkown
HY-124484 JI130 Inhibitor 99.41% Unkown
HY-164410 MO-I-1100 Inhibitor 99.76% Unkown
HY-N2740 Agalloside 98.0% Unkown
HY-RS06134 HES1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N13201 12-Deoxyphorbol 13-palmitate Inducer 99.85% Unkown
HY-RS17070 Hes1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-181975 ATOX1-IN-1 Inhibitor / Unkown
HY-N3393 Lethedioside A Inhibitor / Unkown
HY-RS23514 Hes1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Hes1 NCBI NCBI:3280