HES1 - hes family bHLH transcription factor 1 Gene

Also Known as HHL; HRY; HES-1; bHLHb39

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3280

About HES1

Cytogenetic location: 3q29 Genomic coordinates (GRCh38): 3:194,136,148-194,138,732 (from NCBI)

This gene has 2 transcripts (splice variants), 264 orthologues and 12 paralogues. Ubiquitous expression in prostate (RPKM 46.7), thyroid (RPKM 44.9) and 24 other tissues.

Summary

This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. [provided by RefSeq, Jul 2008]

HES1 Products (1)

mRNA	Protein	Name
NM_005524.4	NP_005515.1	transcription factor HES-1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Verweise	Source
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	12535671	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12535671	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in Notch signaling pathway	IDA IDA: Inferred from direct assay	16160079	GOA
involved in Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	19682396	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12535671	GOA
involved in negative regulation of pro-B cell differentiation	IMP IMP: Inferred from mutant phenotype	12032823	GOA
involved in negative regulation of stem cell differentiation	IMP IMP: Inferred from mutant phenotype	19682396	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12032823	GOA
involved in neuronal stem cell population maintenance	IEP IEP: Inferred from expression pattern	19682396	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HES1 Protein Structure

HLH

Hairy_orange

0
100
200
280 a.a.

Protein Preferred Names	Protein Names
transcription factor HES-1	class B basic helix-loop-helix protein 39

HES1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	HES1	Q14469	SIRT1	Homo sapiens	Q96EB6	Pull Down	12535671
Intra	HES1	Q14469	SIRT1	Homo sapiens	Q96EB6	Anti Tag CoIP	12535671

Cross: Cross-species interaction Intra: Intraspecies interaction

HES1 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P80155	Hes1 Antibody (YA387)	WB, ICC/IF, IHC-P, FC	Human, Mouse, Rat
HY-P86085	HES1 Antibody (YA5777)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Precursor T-Cell Acute Lymphoblastic Leukemia	T-All Precursor T-Cell Acute Lymphoblastic Leukemia/Lymphoma Precursor T-Cell Acute Lymphocytic Leukemia Precursor T-Cell Acute Lymphocytic Leukemia/Lymphoma Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Adult T-Cell Lymphoma/Leukemia
T-Cell Acute Lymphoblastic Leukemia	T-Cell Leukemia Acute T Cell Leukemia Precursor T Lymphoblastic Leukemia Precursor T-Lymphoblastic Lymphoma/Leukemia T Acute Lymphoblastic Leukemia T-Cell Acute Lymphocytic Leukaemia T-Cell Lymphoblastic Leukemia/Lymphoma Leukemia T-Cell Leukemia, T-Cell Leukemia, Acute, Lymphoblastic, T-Cell Leukemia, T-Cell Acute Lymphoblastic Leukemia, Acute T-Cell Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Precursor T-Cell Lymphoblastic Lymphoma Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
Chronic Cholangitis
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (12)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-19369	L-685458		99.69%	Unkown
HY-117113	JI051	Inhibitor	98.0%	Unkown
HY-107245	Segetalin B		99.9%	Unkown
HY-124484	JI130	Inhibitor	99.41%	Unkown
HY-164410	MO-I-1100	Inhibitor	99.76%	Unkown
HY-N2740	Agalloside		98.0%	Unkown
HY-RS06134	HES1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-N13201	12-Deoxyphorbol 13-palmitate	Inducer	99.85%	Unkown
HY-RS17070	Hes1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-181975	ATOX1-IN-1	Inhibitor	/	Unkown
HY-N3393	Lethedioside A	Inhibitor	/	Unkown
HY-RS23514	Hes1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	HES1	VGNC	VGNC:102756
Rattus norvegicus	HES1	RGD	RGD:62081
Macaca mulatta	HES1	VGNC	VGNC:110360
Bos taurus	HES1	VGNC	VGNC:29818
Mus musculus	HES1	MGD	MGI:104853
Others	HES1	NCBI