Hk1 - hexokinase 1 Gene

Also Known as dea; Hk-1; Hk1-s; mHk1-s

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15275

Summary

Enables Glucokinase activity and peptidoglycan binding activity. Involved in carbohydrate phosphorylation; positive regulation of cytokine production involved in immune response; and positive regulation of interleukin-1 beta production. Located in several cellular components, including membrane raft; mitochondrion; and sperm principal piece. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4G; anemia (multiple); hematologic Cancer (multiple); obesity; and retinitis pigmentosa. Orthologous to human HK1 (Hexokinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Hk1 Products (2)

mRNA Protein Name
NM_001146100.1 NP_001139572.1 hexokinase-1 isoform HK1
NM_010438.3 NP_034568.2 hexokinase-1 isoform HK1-sb

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glucokinase activity IDA
IDA: Inferred from direct assay
18509164 MGI
enables hexokinase activity IDA
IDA: Inferred from direct assay
15155459 MGI
enables hexokinase activity IMP
IMP: Inferred from mutant phenotype
27374331 MGI
enables peptidoglycan binding IDA
IDA: Inferred from direct assay
27374331 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
19889946 MGI
Biological Process GO Annotation Evidence References Source
involved in GDP-mannose biosynthetic process from glucose IDA
IDA: Inferred from direct assay
21273394 MGI
involved in GDP-mannose biosynthetic process from mannose IDA
IDA: Inferred from direct assay
21273394 MGI
involved in canonical glycolysis IDA
IDA: Inferred from direct assay
4275392 MGI
involved in carbohydrate phosphorylation IMP
IMP: Inferred from mutant phenotype
27374331 MGI
involved in positive regulation of cytokine production involved in immune response IDA
IDA: Inferred from direct assay
27374331 MGI
involved in positive regulation of interleukin-1 beta production IDA
IDA: Inferred from direct assay
27374331 MGI
Cellular Component GO Annotation Evidence References Source
is active in cytosol IDA
IDA: Inferred from direct assay
12420306 MGI
located in cytosol IDA
IDA: Inferred from direct assay
12420306 MGI
located in membrane raft IDA
IDA: Inferred from direct assay
19144954 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
27374331 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hexokinase-1

  • HK I

  • downeast anemia

  • hexokinase type I

  • hexokinase, tumor isozyme

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-18768 NCT-501 99.59% Unkown
HY-N6954 Garcinone C 99.51% Unkown
HY-P10412 A11 Inhibitor 98.49% Unkown
HY-N20662 (+)-Neoalbaconol / Unkown
HY-RS06192 HK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06287 HOOK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07100 KCNA4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07373 KLK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14138 TAC4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N10133 Licoflavanone / Unkown
HY-RS17121 Hk1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23566 Hk1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991810 Anti-Mouse Ly-6C Antibody (HK1.4) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hk1 NCBI NCBI:3098