Foxa1 - forkhead box A1 Gene

Also Known as Hnf3a; Tcf3a; Hnf-3a; Tcf-3a

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15375

Summary

Enables DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in chromatin remodeling. Acts upstream of or within several processes, including lung development; prostate gland development; and regulation of transcription by RNA polymerase II. Located in microvillus and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human FOXA1 (forkhead box A1). [provided by Alliance of Genome Resources, Apr 2022]

Foxa1 Products (1)

mRNA Protein Name
NM_008259.4 NP_032285.2 hepatocyte nuclear factor 3-alpha

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
15485926 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
10049364 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
10049364 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
22780989 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
8306889 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Notch signaling pathway IDA
IDA: Inferred from direct assay
25446530 MGI
acts upstream of or within alveolar secondary septum development IMP
IMP: Inferred from mutant phenotype
16214823 MGI
acts upstream of or within anatomical structure formation involved in morphogenesis IGI
IGI: Inferred from genetic interaction
23383217 MGI
involved in chromatin remodeling IDA
IDA: Inferred from direct assay
15748903 MGI
acts upstream of or within connective tissue development IGI
IGI: Inferred from genetic interaction
23383217 MGI
acts upstream of dopaminergic neuron differentiation IGI
IGI: Inferred from genetic interaction
17596284 MGI
acts upstream of dopaminergic neuron differentiation IMP
IMP: Inferred from mutant phenotype
17596284 MGI
acts upstream of or within dorsal/ventral neural tube patterning IGI
IGI: Inferred from genetic interaction
23383217 MGI
acts upstream of or within epithelial cell maturation involved in prostate gland development IMP
IMP: Inferred from mutant phenotype
15987773 MGI
acts upstream of or within epithelial tube branching involved in lung morphogenesis IGI
IGI: Inferred from genetic interaction
15668254 MGI
acts upstream of or within glucose homeostasis IMP
IMP: Inferred from mutant phenotype
10049364 MGI
acts upstream of or within hormone metabolic process IMP
IMP: Inferred from mutant phenotype
10049364 MGI
acts upstream of or within lung development IGI
IGI: Inferred from genetic interaction
15668254 MGI
acts upstream of or within lung epithelial cell differentiation IGI
IGI: Inferred from genetic interaction
15668254 MGI
acts upstream of or within lung morphogenesis IMP
IMP: Inferred from mutant phenotype
16214823 MGI
acts upstream of or within mesenchymal-epithelial cell signaling involved in prostate gland development IGI
IGI: Inferred from genetic interaction
15987773 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17220277 MGI
acts upstream of neuron differentiation IGI
IGI: Inferred from genetic interaction
17596284 MGI
acts upstream of neuron differentiation IMP
IMP: Inferred from mutant phenotype
17596284 MGI
acts upstream of or within neuron fate specification IGI
IGI: Inferred from genetic interaction
17596284 MGI
acts upstream of or within positive regulation of dopaminergic neuron differentiation IGI
IGI: Inferred from genetic interaction
17596284 MGI
acts upstream of or within positive regulation of dopaminergic neuron differentiation IMP
IMP: Inferred from mutant phenotype
17596284 MGI
acts upstream of or within positive regulation of smoothened signaling pathway IGI
IGI: Inferred from genetic interaction
23383217 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10049364 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
15539431 MGI
acts upstream of or within prostate gland epithelium morphogenesis IMP
IMP: Inferred from mutant phenotype
15987773 MGI
acts upstream of or within prostate gland stromal morphogenesis IMP
IMP: Inferred from mutant phenotype
15987773 MGI
acts upstream of or within regulation of cell cycle IDA
IDA: Inferred from direct assay
22737085 MGI
acts upstream of or within regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
22737085 MGI
acts upstream of or within regulation of gene expression IGI
IGI: Inferred from genetic interaction
17596284 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
16214823 MGI
acts upstream of or within respiratory basal cell differentiation IMP
IMP: Inferred from mutant phenotype
16214823 MGI
acts upstream of or within secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development IMP
IMP: Inferred from mutant phenotype
15987773 MGI
acts upstream of smoothened signaling pathway IGI
IGI: Inferred from genetic interaction
23383217 MGI
acts upstream of or within tube morphogenesis IMP
IMP: Inferred from mutant phenotype
15987773 MGI
Cellular Component GO Annotation Evidence References Source
located in microvillus IDA
IDA: Inferred from direct assay
23266329 MGI
located in nucleus IDA
IDA: Inferred from direct assay
8306889 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hepatocyte nuclear factor 3-alpha

  • HNF-3-alpha

  • fork head domain

  • forkhead box protein A1

  • hepatocyte nuclear factor 3 alpha (winged helix transcription factor)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-168534 WX-02-23 99.88% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Foxa1 NCBI NCBI:3169