BMT2 - base methyltransferase of 25S rRNA 2 homolog Gene

Also Known as SAMTOR; C7orf60

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 154743

About BMT2

Cytogenetic location: 7q31.1 Genomic coordinates (GRCh38): 7:112,819,147-112,939,875 (from NCBI)

This gene has 3 transcripts (splice variants) and 206 orthologues. Ubiquitous expression in testis (RPKM 5.8), heart (RPKM 5.2) and 25 other tissues.

Summary

Enables S-adenosyl-L-methionine binding activity. Involved in cellular response to amino acid starvation and negative regulation of TORC1 signaling. Colocalizes with GATOR1 complex and KICSTOR complex. [provided by Alliance of Genome Resources, Apr 2022]

BMT2 Products (1)

mRNA Protein Name
NM_152556.3 NP_689769.2 S-adenosylmethionine sensor upstream of mTORC1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables S-adenosyl-L-methionine binding IDA
IDA: Inferred from direct assay
29123071 GOA
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
29123071 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to amino acid starvation IDA
IDA: Inferred from direct assay
29123071 GOA
involved in cellular response to methionine IDA
IDA: Inferred from direct assay
29123071 GOA
involved in positive regulation of TORC1 signaling IDA
IDA: Inferred from direct assay
29123071 GOA
involved in regulation of TORC1 signaling IDA
IDA: Inferred from direct assay
29123071 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BMT2 Protein Structure

Bmt2

Bmt2: 25S rRNA (adenine(2142)-N(1))-methyltransferase, Bmt2 (226 - 320)

  • 0
  • 100
  • 200
  • 300
  • 405 a.a.
Protein Preferred Names Protein Names

S-adenosylmethionine sensor upstream of mTORC1

  • UPF0532 protein C7orf60

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01556 BMT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus BMT2 VGNC VGNC:102007
Bos taurus BMT2 VGNC VGNC:26528
Canis familiaris BMT2 VGNC VGNC:38488
Macaca mulatta BMT2 VGNC VGNC:70398
Rattus norvegicus BMT2 RGD RGD:1588441
Mus musculus BMT2 MGD MGI:2141466
Others BMT2 NCBI