Hspd1 - heat shock protein 1 (chaperonin) Gene

Also Known as 60kDa; CPN60; Hsp60; HSP-60; HSP-65

Species: Mus musculus

Gene Type: protein coding

Gene ID: 15510

Summary

Enables lipopolysaccharide binding activity. Involved in positive regulation of T cell activation. Acts upstream of or within T cell activation; cellular response to interleukin-7; and positive regulation of cytokine production. Located in mitochondrion; plasma membrane; and secretory granule. Is expressed in several structures, including brain; eye; and urinary system. Used to study hereditary spastic paraplegia 13. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autistic disorder; glucose intolerance; hereditary spastic paraplegia (multiple); and hypomyelinating leukodystrophy 4. Orthologous to human HSPD1 (heat shock protein family D (Hsp60) member 1). [provided by Alliance of Genome Resources, Apr 2022]

Hspd1 Products (2)

mRNA	Protein	Name
NM_001356512.1	NP_001343441.1	60 kDa heat shock protein, mitochondrial
NM_010477.4	NP_034607.3	60 kDa heat shock protein, mitochondrial

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables lipopolysaccharide binding	IDA IDA: Inferred from direct assay	17164250	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within T cell activation	IDA IDA: Inferred from direct assay	15371451	MGI
acts upstream of or within T cell activation	IGI IGI: Inferred from genetic interaction	17164250	MGI
NOT involved in adhesion of symbiont to host	IDA IDA: Inferred from direct assay	20633027	MGI
acts upstream of or within cellular response to interleukin-7	IDA IDA: Inferred from direct assay	29581031	MGI
acts upstream of interferon-alpha production	IDA IDA: Inferred from direct assay	17164250	MGI
involved in positive regulation of T cell activation	IDA IDA: Inferred from direct assay	17164250	MGI
acts upstream of or within positive regulation of interferon-alpha production	IDA IDA: Inferred from direct assay	17164250	MGI
acts upstream of or within positive regulation of type II interferon production	IDA IDA: Inferred from direct assay	15371451	MGI
involved in positive regulation of type II interferon production	IDA IDA: Inferred from direct assay	17164250	MGI
acts upstream of or within positive regulation of type II interferon production	IGI IGI: Inferred from genetic interaction	17164250	MGI
acts upstream of type II interferon production	IDA IDA: Inferred from direct assay	15371451	MGI
acts upstream of type II interferon production	IGI IGI: Inferred from genetic interaction	17164250	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	21874024	MGI
located in intracellular membrane-bounded organelle	IDA IDA: Inferred from direct assay	15136728	MGI
located in membrane	IMP IMP: Inferred from mutant phenotype	20080761	MGI
located in migrasome	IDA IDA: Inferred from direct assay	34048705	MGI
is active in mitochondrion	IDA IDA: Inferred from direct assay	26644517	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	1516759	MGI
located in secretory granule	IDA IDA: Inferred from direct assay	1516759	MGI
located in sperm plasma membrane	IDA IDA: Inferred from direct assay	15252132	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
60 kDa heat shock protein, mitochondrial	60 kDa chaperonin chaperonin 60 heat shock 60kDa protein 1 (chaperonin) heat shock protein 60 heat shock protein, 60 kDa mitochondrial matrix protein P1

Recombinant Hspd1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73916	HSP60 Protein, Mouse (His, solution)	P63038 (L2-F573)	≥ 85%, as determined by reducing SDS-PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0890	Tubeimoside I		99.96%	Unkown
HY-115715	EN219		99.21%	Unkown
HY-10996A	KHS101 hydrochloride		99.65%	Unkown
HY-115715A	EN219-alkyne		99.62%	Unkown
HY-10996	KHS101		/	Unkown
HY-N0890R	Tubeimoside I (Standard)	Inducer	/	Unkown
HY-RS06447	HSPD1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18520	Hspd1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25002	Hspd1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hspd1	NCBI	NCBI:3329