Htr4 - 5 hydroxytryptamine (serotonin) receptor 4 Gene

Also Known as 5-HT4; 5HTR4; 5-HT-4; 5-HT

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15562

About Htr4

Chromosome 18: 62,457,275-62,629,648 forward strand.GRCm39:CM001011.3

This gene has 4 transcripts (splice variants), 201 orthologues, 32 paralogues and is associated with 11 phenotypes. Biased expression in bladder adult (RPKM 1.5), colon adult (RPKM 1.5) and 6 other tissues.

Summary

Predicted to enable G protein-coupled serotonin receptor activity; neurotransmitter receptor activity; and serotonin binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway; chemical synaptic transmission; and gamma-aminobutyric acid signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in cytoplasm and membrane. Predicted to be active in dendrite. Predicted to be integral component of plasma membrane. Is expressed in several structures, including brain; gallbladder; genitourinary system; gut; and spinal cord. Used to study anorexia nervosa. Orthologous to human HTR4 (5-hydroxytryptamine receptor 4). [provided by Alliance of Genome Resources, Apr 2022]

Htr4 Products (10)

mRNA Protein Name
NM_001364959.1 NP_001351888.1 5-hydroxytryptamine receptor 4 isoform 5
NM_001364956.1 NP_001351885.1 5-hydroxytryptamine receptor 4 isoform 2
NM_001364957.1 NP_001351886.1 5-hydroxytryptamine receptor 4 isoform 3
NM_001364958.1 NP_001351887.1 5-hydroxytryptamine receptor 4 isoform 4
NM_008313.4 NP_032339.2 5-hydroxytryptamine receptor 4 isoform 1
NM_001364956.1 NP_001351885.1 5-hydroxytryptamine receptor 4 isoform 2
NM_001364957.1 NP_001351886.1 5-hydroxytryptamine receptor 4 isoform 3
NM_001364958.1 NP_001351887.1 5-hydroxytryptamine receptor 4 isoform 4
NM_001364959.1 NP_001351888.1 5-hydroxytryptamine receptor 4 isoform 5
NM_008313.4 NP_032339.2 5-hydroxytryptamine receptor 4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled serotonin receptor activity IDA
IDA: Inferred from direct assay
33299969 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
19661922 MGI
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
33299969 MGI
involved in maintenance of gastrointestinal epithelium IDA
IDA: Inferred from direct assay
33299969 MGI
involved in mucus secretion IDA
IDA: Inferred from direct assay
33299969 MGI
involved in regulation of postsynapse assembly EXP
EXP: Inferred from Experiment
32060357 MGI
involved in regulation of postsynapse assembly IDA
IDA: Inferred from direct assay
32060357 MGI
involved in regulation of postsynapse assembly IMP
IMP: Inferred from mutant phenotype
32060357 MGI
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
32060357 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
29706583 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
32060357 MGI
is active in plasma membrane IDA
IDA: Inferred from direct assay
33299969 MGI
is active in postsynapse IDA
IDA: Inferred from direct assay
29706583 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Htr4 Protein Structure

7tmA_5-HT4

7tmA_5-HT4: cd15056 (19 - 322)

7tmA_5-HT4

7tmA_5-HT4: cd15056 (20 - 46)

7tmA_5-HT4

7tmA_5-HT4: cd15056 (54 - 80)

7tmA_5-HT4

7tmA_5-HT4: cd15056 (92 - 122)

7tmA_5-HT4

7tmA_5-HT4: cd15056 (135 - 158)

7tmA_5-HT4

7tmA_5-HT4: cd15056 (188 - 217)

7tmA_5-HT4

7tmA_5-HT4: cd15056 (251 - 281)

7tmA_5-HT4

7tmA_5-HT4: cd15056 (290 - 315)

  • 0
  • 100
  • 200
  • 300
  • 388 a.a.
Protein Preferred Names Protein Names

5-hydroxytryptamine receptor 4

Htr4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Htr4 P97288 SRC Homo sapiens P12931
Anti Tag CoIP
19661922
Cross
Htr4 P97288 SRC Homo sapiens P12931
Pull Down
19661922
Cross
Htr4 P97288 GRK5 Homo sapiens P34947
Anti Tag CoIP
19661922
Cross
Htr4 P97288 GRK5 Homo sapiens P34947
Competition Binding
19661922
Cross
Htr4 P97288 GRK5 Homo sapiens P34947
Pull Down
19661922
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14153A Tegaserod maleate 99.90% Unkown
HY-14153 Tegaserod 99.71% Unkown

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-14153S Tegaserod-d11 / Unkown
HY-RS06474 HTR4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06475 Htr4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06476 Htr4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Htr4 NCBI NCBI:3360