CYP2J2 - cytochrome P450 family 2 subfamily J member 2 Gene

Also Known as CPJ2; CYPIIJ2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1573

About CYP2J2

Cytogenetic location: 1p32.1 Genomic coordinates (GRCh38): 1:59,893,308-59,969,212 (from NCBI)

This gene has 5 transcripts (splice variants), 151 orthologues and 15 paralogues. Biased expression in small intestine (RPKM 44.5), heart (RPKM 35.2) and 10 other tissues.

Summary

This gene encodes a member of the Cytochrome P450 superfamily of Enzymes. The Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of Cholesterol, Steroids and Other lipids. This protein localizes to the endoplasmic reticulum and is thought to be the predominant enzyme responsible for epoxidation of endogenous arachidonic acid in cardiac tissue. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016]

CYP2J2 Products (1)

mRNA Protein Name
NM_000775.4 NP_000766.2 cytochrome P450 2J2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables arachidonate 11,12-epoxygenase activity IDA
IDA: Inferred from direct assay
11901223 GOA
enables arachidonate 14,15-epoxygenase activity IDA
IDA: Inferred from direct assay
11901223 GOA
enables arachidonate epoxygenase activity IDA
IDA: Inferred from direct assay
8631948 GOA
enables isomerase activity IDA
IDA: Inferred from direct assay
19737933 GOA
enables linoleic acid epoxygenase activity IDA
IDA: Inferred from direct assay
11901223 GOA
Biological Process GO Annotation Evidence References Source
involved in epoxygenase P450 pathway IDA
IDA: Inferred from direct assay
8631948 GOA
involved in icosanoid metabolic process IDA
IDA: Inferred from direct assay
19737933 GOA
involved in linoleic acid metabolic process IDA
IDA: Inferred from direct assay
11901223 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CYP2J2 Protein Structure

p450

p450: Cytochrome P450 (44 - 497)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 502 a.a.
Protein Preferred Names Protein Names

cytochrome P450 2J2

  • albendazole monooxygenase (hydroxylating)

Related Diseases

Diseases Alias
Atherosclerosis Susceptibility

  • Atherosclerosis

  • Atherosclerosis, Susceptibility To

  • ATHS

  • Atherogenic Lipoprotein Phenotype

  • Alp

  • Arteriosclerosis
Hemopericardium

  • Haemopericardium

  • Pericardial Effusion

  • Haematopericardium

  • Pneumohemopericardium

  • Pericardium Haemorrhage

  • Haemorrhagic Pericarditis
Cardiovascular System Disease

  • Abnormality Of The Cardiovascular System

  • Cardiovascular Disease

  • Disease Of Subdivision Of Hemolymphoid System

  • Disorder Of Cardiovascular System

  • Cardiovascular Diseases
Hypertension, Essential

  • Essential Hypertension

  • Hypertension

  • High Blood Pressure

  • Hypertension, Essential, Susceptibility To

  • Hypertensive Disease

  • Primary Hypertension

  • EHT

  • Hypertension, Salt-Sensitive Essential, Susceptibility To

  • Hyperpiesia

  • Idiopathic Hypertension

  • Hypertensive Disorder

  • Hypertension, Essential, Susceptibility To, 3

  • Hypertension, Essential 3

  • Hypertension, Essential, Salt-Sensitive

  • Hypertension, Essential, Susceptibility To, 6

  • Hypertension, Essential 6

  • Hypertension, Salt-Sensitive Essential

  • Hypertension, Susceptibility To

  • Hypertension, Essential, Susceptibility To, 4

  • Hypertension, Essential 4

  • Hypertension, Essential, Susceptibility To, 2

  • Hypertension, Essential 2

  • Hypertension, Essential, Susceptibility To, 1

  • Hypertension, Essential 1

  • Hypertension, Essential, Susceptibility To, 5

  • Hypertension, Essential 5

  • Htn

  • Vascular Hypertensive Disorder

  • Systemic Primary Arterial Hypertension

  • Hbp - [High Blood Pressure]

  • Systemic Arterial Hypertensive Disorder

  • Elevated Blood Pressure

  • Arterial Hypertension Nos

  • Hypertension Nos

  • Benign Hypertension

  • Systemic Arterial Hypertension

  • Systemic Hypertension

  • Artery Htn

  • Benign Htn

  • Vascular Htn

  • Vascular Hypertension

  • Cholesterol Hypertension

  • Cholesterol Htn

  • Idiopathic Htn

  • Malignant Hypertension

  • Malignant Htn

  • Raised Blood Pressure

  • Cardiovascular Hypertension

  • Primary Htn - [Hypertension]

  • High Arterial Tension

  • High Blood Pressure Disorder

  • Ht - [Hypertension]

  • Htn - [Hypertension]

  • Hypertensive Vascular Disease

  • Hypertensive Vascular Degeneration
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-109173 Filapixant 99.10% Phase 2

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0319 Salvianolic acid C Inhibitor 99.94% Unkown
HY-N0515 Ophiopogonin D 99.80% Unkown
HY-117026 LKY-047 Inhibitor 99.94% Unkown
HY-122508 Hydroxyebastine 97.33% Unkown
HY-RS03465 CYP2J2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CYP2J2 RGD RGD:620007
Macaca mulatta CYP2J2 VGNC VGNC:99873
Felis catus CYP2J2 VGNC VGNC:103321
Canis familiaris CYP2J2 VGNC VGNC:50354
Others CYP2J2 NCBI