Ica1 - islet cell autoantigen 1 Gene

Also Known as 69kDa; ICA69

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15893

Summary

Predicted to enable membrane curvature sensor activity and protein domain specific binding activity. Predicted to be involved in regulation of protein-containing complex assembly and regulation of transport. Predicted to act upstream of or within neurotransmitter transport. Located in cytosol and synaptic vesicle membrane. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and trigeminal nerve. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human ICA1 (islet cell autoantigen 1). [provided by Alliance of Genome Resources, Apr 2022]

Ica1 Products (10)

mRNA Protein Name
NM_001252266.2 NP_001239195.1 islet cell autoantigen 1 isoform 2
NM_001410043.1 NP_001396972.1 islet cell autoantigen 1 isoform 1
NM_001410044.1 NP_001396973.1 islet cell autoantigen 1 isoform 1
NM_001410045.1 NP_001396974.1 islet cell autoantigen 1 isoform 2
NM_001410046.1 NP_001396975.1 islet cell autoantigen 1 isoform 2
NM_001410047.1 NP_001396976.1 islet cell autoantigen 1 isoform 3
NM_001410048.1 NP_001396977.1 islet cell autoantigen 1 isoform 4
NM_001410049.1 NP_001396978.1 islet cell autoantigen 1 isoform 5
NM_001410050.1 NP_001396979.1 islet cell autoantigen 1 isoform 6
NM_010492.4 NP_034622.3 islet cell autoantigen 1 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23630453 MGI
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
11029035 MGI
located in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
11029035 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

islet cell autoantigen 1

  • 69 kDa islet cell autoantigen

  • ICAp69

  • islet cell autoantigen 1, 69 kDa

  • islet cell autoantigen p69

  • p69

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-183252 ICA-1S / Unkown
HY-RS06511 ICA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17958 Ica1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24429 Ica1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ica1 NCBI NCBI:3382