Il1rap - interleukin 1 receptor accessory protein Gene

Also Known as IL-1RAcP; 6430709H04Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16180

Summary

Enables interleukin-1 receptor activity; interleukin-33 receptor activity; and protein tyrosine kinase binding activity. Involved in several processes, including interleukin-33-mediated signaling pathway; positive regulation of cytokine production; and regulation of synapse assembly. Acts upstream of or within cytokine-mediated signaling pathway; positive regulation of dendrite development; and positive regulation of synapse assembly. Located in glutamatergic synapse. Is expressed in dorsal aorta; future brain; genitourinary system; liver; and ventral grey horn. Orthologous to human IL1RAP (interleukin 1 receptor accessory protein). [provided by Alliance of Genome Resources, Apr 2022]

Il1rap Products (4)

mRNA Protein Name
NM_001159317.1 NP_001152789.1 interleukin-1 receptor accessory protein isoform c precursor
NM_001159318.1 NP_001152790.1 interleukin-1 receptor accessory protein isoform d precursor
NM_008364.2 NP_032390.1 interleukin-1 receptor accessory protein isoform a precursor
NM_134103.2 NP_598864.1 interleukin-1 receptor accessory protein isoform b precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables interleukin-1 receptor activity IDA
IDA: Inferred from direct assay
11880380 MGI
enables interleukin-33 receptor activity IMP
IMP: Inferred from mutant phenotype
17675517 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10854325 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cytokine-mediated signaling pathway IDA
IDA: Inferred from direct assay
11880380 MGI
acts upstream of or within interleukin-2 production IDA
IDA: Inferred from direct assay
11880380 MGI
involved in interleukin-33-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
17675517 MGI
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
18003919 MGI
involved in positive regulation of interleukin-13 production IMP
IMP: Inferred from mutant phenotype
17675517 MGI
involved in positive regulation of interleukin-4 production IMP
IMP: Inferred from mutant phenotype
17675517 MGI
involved in positive regulation of interleukin-5 production IMP
IMP: Inferred from mutant phenotype
17675517 MGI
involved in positive regulation of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
18003919 MGI
involved in positive regulation of synapse assembly IDA
IDA: Inferred from direct assay
25908590 MGI
involved in regulation of postsynaptic density assembly IDA
IDA: Inferred from direct assay
22357843 MGI
involved in regulation of postsynaptic density assembly IMP
IMP: Inferred from mutant phenotype
22357843 MGI
involved in regulation of presynapse assembly IDA
IDA: Inferred from direct assay
22357843 MGI
involved in regulation of presynapse assembly IMP
IMP: Inferred from mutant phenotype
22357843 MGI
involved in synaptic membrane adhesion IDA
IDA: Inferred from direct assay
22357843 MGI
involved in synaptic membrane adhesion IMP
IMP: Inferred from mutant phenotype
22357843 MGI
involved in trans-synaptic signaling by trans-synaptic complex IDA
IDA: Inferred from direct assay
22357843 MGI
involved in trans-synaptic signaling by trans-synaptic complex IMP
IMP: Inferred from mutant phenotype
22357843 MGI
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
22357843 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
22357843 MGI
is active in synapse IDA
IDA: Inferred from direct assay
22357843 MGI
is active in synapse IMP
IMP: Inferred from mutant phenotype
22357843 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interleukin-1 receptor accessory protein

  • IL-1 receptor accessory protein

  • interleukin-33 receptot beta chain

Il1rap Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Il1rap Q61730 Il1rl1 Mus musculus P14719
Anti Tag CoIP
18003919
Intra
Il1rap Q61730 Tollip Mus musculus Q9QZ06
CoIP
10854325
Intra
Il1rap Q61730 Tollip Mus musculus Q9QZ06
Y2H
10854325
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Il1rap Proteins

Cat. No. Product Name Accession Purity
HY-P77417 IL-1RAcP/IL-1 R3 Protein, Mouse (HEK293, Fc) Q61730-1 (S21-K350) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78311 IL-1RAcP/IL-1 R3 Protein, Mouse (HEK293, His) Q61730-1 (S21-T367) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99379 Nidanilimab (Nadunolimab) Inhibitor 99.90% Phase 2
HY-P991267 CAN10 Inhibitor 95.04% Phase 1

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06722 IL1RAP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24078 Il1rap Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17618 Il1rap Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992026 ADV-101 Antibody / Unkown
HY-P992027 CSC012 Antibidy / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il1rap NCBI NCBI:3556