IL-1 Receptor Accessory Proteins
Interleukin-1 receptor accessory protein (IL-1RAcP) (EC:3.2.2.6), also known as IL-1 R3, belongs to the immunoglobulin (Ig) superfamily. It contains three Ig-like domains and a cytoplasmic domain named Toll/IL-1 receptor (TIR), which has been implicated in signal transduction. IL-1RAcP also contains a single transmembrane region. IL-1RAcP can be detected in liver, skin, placenta, thymus and lung. There are four isoforms of IL-1RAcP, the membranous form plays an important role in IL-1, IL-33, IL-36 signing, as well as FLT3 and C-Kit in AML cells. The isoform 2 and 3 are soluble forms, contribute to the regulation of the inflammation induced by IL-1. The isoform 4 is mainly expressed in CNS neurons. IL-1RAcP is an essential component of the IL-1 receptor and can be used for the research of inflammatory disorders. The sequence of amino acids in IL-1RAcP proteins from different species is relatively stable (over 85% identity between human, mouse and rat)[1][2].
- [1]. Neveu PJ, et al. Mechanisms of behavioral and neuroendocrine effects of interleukin-1 in mice. Ann N Y Acad Sci. 2000;917:175-85. [Content Brief]
- [2]. Zarezadeh Mehrabadi A, et al. The roles of interleukin-1 receptor accessory protein in certain inflammatory conditions. Immunology. 2022 May;166(1):38-46. [Content Brief]
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IL-1 Receptor Accessory Recombinant Proteins (10)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
