Insr - insulin receptor Gene

Also Known as IR; IR-A; IR-B; CD220; 4932439J01Rik; D630014A15Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16337

About Insr

Chromosome 8: 3,172,061-3,329,617 reverse strand.GRCm39:CM001001.3

This gene has 5 transcripts (splice variants), 289 orthologues, 53 paralogues and is associated with 27 phenotypes. Ubiquitous expression in heart adult (RPKM 8.5), adrenal adult (RPKM 7.8) and 28 other tissues.

Summary

This gene encodes a member of the receptor tyrosine kinase family of transmembrane signaling proteins that play important roles in cell differentiation, growth and metabolism. The encoded preproprotein undergoes proteolytic processing to generate alpha and beta chains that form a disulfide-linked heterodimer which, in turn homodimerizes to form a mature, functional receptor. Mice lacking the encoded protein develop severe hyperglycemia and hyperketonemia, and die within a couple of days after birth as a result of diabetic ketoacidosis. [provided by RefSeq, Aug 2016]

Insr Products (2)

mRNA Protein Name
NM_001330056.1 NP_001316985.1 insulin receptor isoform B preproprotein
NM_010568.3 NP_034698.2 insulin receptor isoform A preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables insulin receptor activity IDA
IDA: Inferred from direct assay
2557333 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
8621530 MGI
enables protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
8448209 MGI
enables protein tyrosine kinase activity IGI
IGI: Inferred from genetic interaction
9038347 MGI
Biological Process GO Annotation Evidence References Source
involved in adrenal gland development IGI
IGI: Inferred from genetic interaction
23300479 MGI
acts upstream of or within animal organ morphogenesis IMP
IMP: Inferred from mutant phenotype
12101187 MGI
acts upstream of or within cellular response to growth factor stimulus IDA
IDA: Inferred from direct assay
19744960 MGI
acts upstream of or within epidermis development IMP
IMP: Inferred from mutant phenotype
23906066 MGI
acts upstream of or within exocrine pancreas development IMP
IMP: Inferred from mutant phenotype
12101187 MGI
involved in insulin receptor signaling pathway IDA
IDA: Inferred from direct assay
8448209 MGI
involved in insulin receptor signaling pathway IGI
IGI: Inferred from genetic interaction
9038347 MGI
acts upstream of or within insulin receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
12488434 MGI
involved in insulin receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
20032056 MGI
involved in male gonad development IGI
IGI: Inferred from genetic interaction
23300479 MGI
acts upstream of or within male sex determination IMP
IMP: Inferred from mutant phenotype
14628051 MGI
acts upstream of or within peptidyl-tyrosine autophosphorylation IDA
IDA: Inferred from direct assay
10100151 MGI
involved in positive regulation of DNA-templated transcription IGI
IGI: Inferred from genetic interaction
23300479 MGI
acts upstream of positive regulation of glycogen biosynthetic process IMP
IMP: Inferred from mutant phenotype
20032056 MGI
involved in positive regulation of meiotic cell cycle IGI
IGI: Inferred from genetic interaction
23300479 MGI
acts upstream of or within positive regulation of mitotic nuclear division IMP
IMP: Inferred from mutant phenotype
23906066 MGI
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
20032056 MGI
acts upstream of positive effect receptor internalization IDA
IDA: Inferred from direct assay
17264162 MGI
involved in regulation of female gonad development IGI
IGI: Inferred from genetic interaction
23300479 MGI
Cellular Component GO Annotation Evidence References Source
located in caveola IDA
IDA: Inferred from direct assay
16513830 MGI
located in membrane IDA
IDA: Inferred from direct assay
9447983 MGI
is active in plasma membrane IDA
IDA: Inferred from direct assay
2557333 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
14562105 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Insr Protein Structure

Recep_L_domain

Recep_L_domain: pfam01030 (51 - 163)

Furin-like

Furin-like: pfam00757 (178 - 336)

Recep_L_domain

Recep_L_domain: pfam01030 (358 - 471)

FN3

FN3: cd00063 (623 - 666)

FN3

FN3: cd00063 (856 - 933)

Insulin_TMD

Insulin_TMD: pfam17870 (929 - 976)

PTKc_InsR

PTKc_InsR: cd05061 (1005 - 1292)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1372 a.a.
Protein Preferred Names Protein Names

insulin receptor

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15656 Ceritinib Inhibitor 99.95% Yes
HY-15656A Ceritinib dihydrochloride Inhibitor 99.90% Yes
HY-15656AR Ceritinib dihydrochloride (Standard) Inhibitor / Unkown
HY-15656R Ceritinib (Standard) Inhibitor 99.72% Unkown

Clinical Phase

Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P990712 Ersodetug Inhibitor 99.33% Phase 3
HY-P991037 Verenafusp alfa / Phase 1

Pre-clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-50866 NVP-AEW541 99.92% Unkown
HY-13203 NVP-TAE 226 99.77% Unkown
HY-10252 NVP-ADW742 99.30% Unkown
HY-15656S Ceritinib-d7 Inhibitor 98.00% Unkown
HY-RS06847 Insr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-50866B NVP-AEW541 dihydrochloride / Unkown
HY-10252A cis-NVP-ADW742 Inhibitor / Unkown
HY-108230 ALK-IN-12 Inhibitor / Unkown
HY-15656B Ceritinib mesylate Inhibitor / Unkown
HY-169066 INSR agonist 1 Agonist / Unkown
HY-180972 PROTAC EML4-ALK Degrader-2 Inhibitor / Unkown
HY-183292 SH-1092 Inhibitor / Unkown
HY-E70730 INSR Recombinant Human Active Protein Kinase / Unkown
HY-RS06846 INSR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06848 Insr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991290 IRAB-B Antagonist 98.30% Unkown
HY-P991291 XOMA 129 Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Insr NCBI NCBI:3643