2. Gene
  3. Insr - insulin receptor Gene

Insr - insulin receptor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as IR; IR-A; IR-B; CD220; 4932439J01Rik; D630014A15Rik

Gene ID: 16337 | Gene type: protein coding

About Insr

Chromosome 8: 3,172,061-3,329,617 reverse strand.GRCm39:CM001001.3

This gene has 5 transcripts (splice variants), 289 orthologues, 53 paralogues and is associated with 27 phenotypes. Ubiquitous expression in heart adult (RPKM 8.5), adrenal adult (RPKM 7.8) and 28 other tissues.

Summary

This gene encodes a member of the receptor tyrosine kinase family of transmembrane signaling proteins that play important roles in cell differentiation, growth and metabolism. The encoded preproprotein undergoes proteolytic processing to generate alpha and beta chains that form a disulfide-linked heterodimer which, in turn homodimerizes to form a mature, functional receptor. Mice lacking the encoded protein develop severe hyperglycemia and hyperketonemia, and die within a couple of days after birth as a result of diabetic ketoacidosis. [provided by RefSeq, Aug 2016]

Insr Products(2)

mRNA Protein Name
NM_001330056.1 NP_001316985.1 insulin receptor isoform B preproprotein
NM_010568.3 NP_034698.2 insulin receptor isoform A preproprotein

Insr Protein Structure

Recep_L_domain

Recep_L_domain: pfam01030 (51 - 163)

Furin-like

Furin-like: pfam00757 (178 - 336)

Recep_L_domain

Recep_L_domain: pfam01030 (358 - 471)

FN3

FN3: cd00063 (623 - 666)

FN3

FN3: cd00063 (856 - 933)

Insulin_TMD

Insulin_TMD: pfam17870 (929 - 976)

PTKc_InsR

PTKc_InsR: cd05061 (1005 - 1292)

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  • 1372 a.a.
Protein Preferred Names Protein Names

insulin receptor

Recombinant Insr Proteins

Cat. No. Product Name Accession Purity
HY-P79275 Insulin R/CD220 Protein, Mouse (CHO, His) P15208 (H28-S748) & P15208 (S753-K946) ≥95%

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15656 Ceritinib Inhibitor 99.98% Yes
HY-15656A Ceritinib dihydrochloride Inhibitor 99.57% Yes
Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-50866 NVP-AEW541 99.92% Unkown
HY-10252 NVP-ADW742 99.54% Unkown
HY-13203 NVP-TAE 226 99.92% Unkown
HY-50866B NVP-AEW541 dihydrochloride / Unkown
HY-108230 ALK-IN-12 Inhibitor / Unkown
HY-RS06846 INSR Human Pre-designed siRNA Set A / Unkown
HY-RS06847 Insr Mouse Pre-designed siRNA Set A / Unkown
HY-RS06848 Insr Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Insr NCBI NCBI:3643