Irf1 - interferon regulatory factor 1 Gene

Also Known as Irf-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16362

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in several processes, including defense response to Other organism; regulation of T cell activation; and regulation of gene expression. Acts upstream of or within CD8-positive, alpha-beta T cell differentiation; positive regulation of interleukin-12 production; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including early conceptus; eye; genitourinary system; and gut. Human ortholog(s) of this gene implicated in asthma; gastric adenocarcinoma; lung non-small cell carcinoma; and smallpox. Orthologous to human IRF1 (interferon regulatory factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Irf1 Products (3)

mRNA Protein Name
NM_001159393.1 NP_001152865.1 interferon regulatory factor 1 isoform b
NM_001159396.1 NP_001152868.1 interferon regulatory factor 1 isoform a
NM_008390.2 NP_032416.1 interferon regulatory factor 1 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
14568984 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
14568984 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
25774715 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
30635240 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17018642 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
17159910 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within CD8-positive, alpha-beta T cell differentiation IMP
IMP: Inferred from mutant phenotype
11359801 MGI
involved in defense response to virus IMP
IMP: Inferred from mutant phenotype
20451243 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
18641303 MGI
involved in negative regulation of regulatory T cell differentiation IMP
IMP: Inferred from mutant phenotype
18641303 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
14568984 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
20308629 MGI
acts upstream of or within positive regulation of interleukin-12 production IDA
IDA: Inferred from direct assay
14568984 MGI
acts upstream of or within positive regulation of interleukin-12 production IMP
IMP: Inferred from mutant phenotype
14568984 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17159910 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
30635240 MGI
involved in positive regulation of type I interferon production IMP
IMP: Inferred from mutant phenotype
17018642 MGI
involved in regulation of CD8-positive, alpha-beta T cell proliferation IMP
IMP: Inferred from mutant phenotype
21909274 MGI
involved in regulation of MyD88-dependent toll-like receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
17018642 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
11359801 MGI
acts upstream of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17159910 MGI
involved in type II interferon-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
21909274 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
17018642 MGI
located in nucleus IDA
IDA: Inferred from direct assay
17018642 MGI
located in nucleus IMP
IMP: Inferred from mutant phenotype
30635240 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interferon regulatory factor 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-171006 IRF1-IN-1 Inhibitor 99.72% Unkown
HY-171007 IRF1-IN-2 99.83% Unkown
HY-108052 Delphinidin 3-glucoside chloride 99.89% Unkown
HY-133897 (Rac)-Indoximod 99.60% Unkown
HY-Y0148 10-Hydroxydecanoic acid Inhibitor 99.77% Unkown
HY-RS06902 IRF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-176222 IRF1 antagonist 1 Inhibitor 98.87% Unkown
HY-17663 KMR-206 98.86% Unkown
HY-RS16716 Irf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-183519 AH057 Inhibitor / Unkown
HY-RS23151 Irf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Irf1 NCBI NCBI:3659