Itpa - inosine triphosphatase (nucleoside triphosphate pyrophosphatase) Gene

Also Known as Itp; ITPase; NTPase; 2010016I08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16434

Summary

Enables dITP diphosphatase activity. Acts upstream of or within ITP catabolic process and chromosome organization. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); developmental and epileptic encephalopathy 35; hepatitis C; rheumatoid arthritis; and thrombocytopenia. Orthologous to human ITPA (inosine triphosphatase). [provided by Alliance of Genome Resources, Apr 2022]

Itpa Products (2)

mRNA Protein Name
NM_001362648.1 NP_001349577.1 inosine triphosphate pyrophosphatase isoform 2
NM_025922.3 NP_080198.2 inosine triphosphate pyrophosphatase isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables dITP diphosphatase activity IMP
IMP: Inferred from mutant phenotype
20081199 MGI
enables nucleoside triphosphate diphosphatase activity IDA
IDA: Inferred from direct assay
1914521 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within ITP catabolic process IMP
IMP: Inferred from mutant phenotype
20081199 MGI
acts upstream of or within chromosome organization IMP
IMP: Inferred from mutant phenotype
20081199 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

inosine triphosphate pyrophosphatase

  • non-canonical purine NTP pyrophosphatase

  • non-standard purine NTP pyrophosphatase

  • nucleoside triphosphate pyrophosphatase

  • nucleoside-triphosphate diphosphatase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-16965 TH287 Inhibitor 98.99% Unkown
HY-RS06986 ITPA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-16965A TH287 hydrochloride Inhibitor / Unkown
HY-RS20758 Itpa Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27271 Itpa Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Itpa NCBI NCBI:3704