Itpr3 - inositol 1,4,5-triphosphate receptor 3 Gene

Also Known as tf; Ip3r3; IP3R 3; Itpr-3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16440

Summary

Enables inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity and phosphatidylinositol binding activity. Involved in calcium ion transport into cytosol. Acts upstream of or within several processes, including long-term synaptic potentiation; memory; and sensory perception of taste. Located in endoplasmic reticulum membrane; nucleolus; and nucleoplasm. Is expressed in several structures, including jaw; liver; sensory organ; skeleton; and spleen. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human ITPR3 (inositol 1,4,5-trisphosphate receptor type 3). [provided by Alliance of Genome Resources, Apr 2022]

Itpr3 Products (1)

mRNA Protein Name
NM_080553.3 NP_542120.2 inositol 1,4,5-trisphosphate receptor type 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables inositol 1,4,5-trisphosphate-gated calcium channel activity IDA
IDA: Inferred from direct assay
9065779 MGI
enables intracellularly gated calcium channel activity IDA
IDA: Inferred from direct assay
20813840 MGI
enables phosphatidylinositol binding IDA
IDA: Inferred from direct assay
17327232 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16352659 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within calcium ion transport IDA
IDA: Inferred from direct assay
15890645 MGI
acts upstream of or within long-term synaptic potentiation IMP
IMP: Inferred from mutant phenotype
18417102 MGI
acts upstream of or within memory IMP
IMP: Inferred from mutant phenotype
18417102 MGI
acts upstream of or within sensory perception of bitter taste IMP
IMP: Inferred from mutant phenotype
17925404 MGI
acts upstream of or within sensory perception of sweet taste IMP
IMP: Inferred from mutant phenotype
17925404 MGI
acts upstream of or within sensory perception of umami taste IMP
IMP: Inferred from mutant phenotype
17925404 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16014380 MGI
located in cytoplasmic side of endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
21030605 MGI
located in nucleolus IDA
IDA: Inferred from direct assay
16014380 MGI
located in nucleoplasm IDA
IDA: Inferred from direct assay
16014380 MGI
located in nucleus IDA
IDA: Inferred from direct assay
16014380 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

inositol 1,4,5-trisphosphate receptor type 3

  • IP3 receptor

  • insP3R3

  • type 3 InsP3 receptor

  • type 3 inositol 1,4,5-trisphosphate receptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06993 ITPR3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21604 Itpr3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28122 Itpr3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Itpr3 NCBI NCBI:3710