Jag1 - jagged 1 Gene

Also Known as Htu; Ozz; ABE2; Ser-1; Gena228; Gsfabe2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16449

Summary

Enables Notch binding activity. Involved in several processes, including circulatory system development; glomerular visceral epithelial cell development; and positive regulation of Notch signaling pathway. Acts upstream of or within several processes, including animal organ development; negative regulation of cell differentiation; and positive regulation of cell differentiation. Located in adherens junction and apical plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Used to study Alagille syndrome. Human ortholog(s) of this gene implicated in Alagille syndrome; congenital heart disease; multiple sclerosis; and tetralogy of Fallot. Orthologous to human JAG1 (jagged canonical Notch ligand 1). [provided by Alliance of Genome Resources, Apr 2022]

Jag1 Products (1)

mRNA Protein Name
NM_013822.5 NP_038850.1 protein jagged-1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables Notch binding IPI
IPI: Inferred from physical interaction
10551863 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15574878 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Notch signaling pathway IDA
IDA: Inferred from direct assay
15574878 MGI
acts upstream of or within Notch signaling pathway IGI
IGI: Inferred from genetic interaction
25406395 MGI
involved in Notch signaling pathway IMP
IMP: Inferred from mutant phenotype
19509466 MGI
acts upstream of or within animal organ morphogenesis IMP
IMP: Inferred from mutant phenotype
11181574 MGI
involved in aorta morphogenesis IMP
IMP: Inferred from mutant phenotype
19509466 MGI
acts upstream of or within blood vessel remodeling IMP
IMP: Inferred from mutant phenotype
10196361 MGI
acts upstream of or within camera-type eye development IMP
IMP: Inferred from mutant phenotype
10196361 MGI
involved in cardiac neural crest cell development involved in outflow tract morphogenesis IMP
IMP: Inferred from mutant phenotype
19509466 MGI
involved in cardiac right ventricle morphogenesis IMP
IMP: Inferred from mutant phenotype
19509466 MGI
involved in cardiac septum morphogenesis IMP
IMP: Inferred from mutant phenotype
19509466 MGI
acts upstream of or within ciliary body morphogenesis IMP
IMP: Inferred from mutant phenotype
23676271 MGI
involved in distal tubule development IEP
IEP: Inferred from expression pattern
15821257 MGI
involved in endocardial cushion cell development IMP
IMP: Inferred from mutant phenotype
19509466 MGI
acts upstream of or within inhibition of neuroepithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
15064243 MGI
acts upstream of or within inner ear auditory receptor cell differentiation IMP
IMP: Inferred from mutant phenotype
16495313 MGI
involved in inner ear development IMP
IMP: Inferred from mutant phenotype
19389353 MGI
involved in loop of Henle development IEP
IEP: Inferred from expression pattern
15821257 MGI
acts upstream of or within morphogenesis of an epithelial sheet IMP
IMP: Inferred from mutant phenotype
11861489 MGI
involved in negative regulation of endothelial cell differentiation IDA
IDA: Inferred from direct assay
25535084 MGI
acts upstream of or within negative regulation of fat cell differentiation IDA
IDA: Inferred from direct assay
15060169 MGI
acts upstream of or within negative regulation of neuron differentiation IMP
IMP: Inferred from mutant phenotype
15064243 MGI
involved in nephron development IMP
IMP: Inferred from mutant phenotype
23806616 MGI
acts upstream of neuroendocrine cell differentiation IMP
IMP: Inferred from mutant phenotype
15064243 MGI
acts upstream of neuron differentiation IMP
IMP: Inferred from mutant phenotype
20081190 MGI
involved in podocyte development IMP
IMP: Inferred from mutant phenotype
23806616 MGI
involved in positive regulation of Notch signaling pathway IDA
IDA: Inferred from direct assay
10958687 MGI
acts upstream of or within positive regulation of myeloid cell differentiation IDA
IDA: Inferred from direct assay
15845452 MGI
acts upstream of or within positive regulation of osteoblast differentiation IDA
IDA: Inferred from direct assay
23980096 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
19509466 MGI
acts upstream of or within regulation of epithelial cell proliferation IGI
IGI: Inferred from genetic interaction
25406395 MGI
involved in response to muramyl dipeptide IDA
IDA: Inferred from direct assay
21156799 MGI
Cellular Component GO Annotation Evidence References Source
located in adherens junction IDA
IDA: Inferred from direct assay
24715457 MGI
located in apical part of cell IDA
IDA: Inferred from direct assay
15821257 MGI
located in apical plasma membrane IDA
IDA: Inferred from direct assay
24715457 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
16000382 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein jagged-1

  • Serrate-1

Recombinant Jag1 Proteins

Cat. No. Product Name Accession Purity
HY-P71633 Jagged-1/JAG1 Protein, Mouse (Myc, His-SUMO) Q9QXX0 (G33-E334) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1846A Jagged-1 (188-204) TFA Agonist 99.89% Unkown
HY-P1846 Jagged-1 (188-204) Agonist 99.72% Unkown
HY-P1849A JAG-1, scrambled TFA Control 99.75% Unkown
HY-RS16717 Jag1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07012 JAG1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23152 Jag1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991860 Anti-JAG1/CD339 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Jag1 NCBI NCBI:182