Klf1 - Kruppel-like factor 1 (erythroid) Gene

Also Known as Nan; Eklf

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16596

Summary

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in erythrocyte differentiation; positive regulation of gene expression; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including chromatin remodeling; hemopoiesis; and liver development. Predicted to be located in chromatin and nucleoplasm. Is expressed in several structures, including extraembryonic component; hemolymphoid system; olfactory placode; testis; and urethra. Used to study beta thalassemia and hereditary spherocytosis. Human ortholog(s) of this gene implicated in congenital dyserythropoietic anemia type IV. Orthologous to human KLF1 (Kruppel like factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Klf1 Products (1)

mRNA Protein Name
NM_010635.3 NP_034765.3 Krueppel-like factor 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
22835905 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
17442339 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
17442339 MGI
enables DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
22835905 MGI
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
19251649 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
17442339 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
19251649 MGI
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
19251649 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within chromatin remodeling IDA
IDA: Inferred from direct assay
15489291 MGI
acts upstream of or within embryonic hemopoiesis IMP
IMP: Inferred from mutant phenotype
7753194 MGI
acts upstream of or within erythrocyte development IMP
IMP: Inferred from mutant phenotype
7753194 MGI
involved in erythrocyte differentiation IMP
IMP: Inferred from mutant phenotype
22835905 MGI
acts upstream of or within erythrocyte maturation IMP
IMP: Inferred from mutant phenotype
7753195 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
7753194 MGI
acts upstream of or within liver development IMP
IMP: Inferred from mutant phenotype
7753194 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
19251649 MGI
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
22835905 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19251649 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17442339 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

Krueppel-like factor 1

  • erythroid krueppel-like transcription factor

  • erythroid transcription factor

  • neonatal anemia

Orthologs Information

Species Symbol Source ID
Homo sapiens Klf1 NCBI NCBI:10661