Krt14 - keratin 14 Gene

Also Known as K14; CK-14; Krt1-14; Krt-1.14

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16664

Summary

This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the Cytoskeleton of epithelial cells. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Krt14 Products (3)

mRNA Protein Name
NM_001313956.1 NP_001300885.1 keratin, type I cytoskeletal 14 isoform 2
NM_001313957.1 NP_001300886.1 keratin, type I cytoskeletal 14 isoform 3
NM_016958.2 NP_058654.1 keratin, type I cytoskeletal 14 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11408584 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within keratinocyte differentiation IDA
IDA: Inferred from direct assay
19303854 MGI
acts upstream of or within response to radiation IDA
IDA: Inferred from direct assay
30305288 MGI
acts upstream of or within stem cell differentiation IDA
IDA: Inferred from direct assay
19303854 MGI
Cellular Component GO Annotation Evidence References Source
located in basal part of cell IDA
IDA: Inferred from direct assay
23599337 MGI
located in cell periphery IDA
IDA: Inferred from direct assay
11698679 MGI
is active in cornified envelope IDA
IDA: Inferred from direct assay
26644517 MGI
located in intracellular anatomical structure IDA
IDA: Inferred from direct assay
16489008 MGI
located in keratin filament IDA
IDA: Inferred from direct assay
14673151 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

keratin, type I cytoskeletal 14

  • cytokeratin 14

  • keratin complex 1, acidic, gene 14

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-179587 1,2,3-Triazole-PEG8-amine / Unkown
HY-179588 PROTAC BET Degrader-14 / Unkown
HY-179589 JQ-1 (carboxylic acid)-amine-PEG8-cyanogen Degrader / Unkown
HY-RS07437 KRT14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19703 Krt14 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26198 Krt14 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Krt14 NCBI NCBI:3861