Krt8 - keratin 8 Gene

Also Known as K8; Card2; EndoA; Krt2-8; Krt-2.8

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16691

Summary

Predicted to enable scaffold protein binding activity. Acts upstream of or within several processes, including cell differentiation involved in embryonic placenta development; cell surface receptor signaling pathway; and hepatocyte apoptotic process. Located in several cellular components, including Z disc; apicolateral plasma membrane; and sarcolemma. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in liver cirrhosis. Orthologous to human KRT8 (keratin 8). [provided by Alliance of Genome Resources, Apr 2022]

Krt8 Products (1)

mRNA Protein Name
NM_031170.2 NP_112447.2 keratin, type II cytoskeletal 8

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10747083 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell differentiation involved in embryonic placenta development IGI
IGI: Inferred from genetic interaction
11062258 MGI
acts upstream of or within extrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
10747083 MGI
acts upstream of or within hepatocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
10747083 MGI
acts upstream of or within response to other organism IMP
IMP: Inferred from mutant phenotype
14576356 MGI
acts upstream of or within tumor necrosis factor-mediated signaling pathway IGI
IGI: Inferred from genetic interaction
10747083 MGI
acts upstream of or within tumor necrosis factor-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
10747083 MGI
Cellular Component GO Annotation Evidence References Source
located in Z disc IDA
IDA: Inferred from direct assay
15247274 MGI
located in apicolateral plasma membrane IDA
IDA: Inferred from direct assay
25232867 MGI
located in cell periphery IDA
IDA: Inferred from direct assay
19487454 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
23266329 MGI
located in intermediate filament IDA
IDA: Inferred from direct assay
10747083 MGI
located in sarcolemma IDA
IDA: Inferred from direct assay
15247274 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

keratin, type II cytoskeletal 8

  • CK-8

  • cytokeratin endo A

  • cytokeratin-8

  • keratin complex 2, basic, gene 8

  • type-II keratin Kb8

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07467 KRT8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18137 Krt8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24612 Krt8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Krt8 NCBI NCBI:3856