Lgals3 - lectin, galactose binding, soluble 3 Gene

Also Known as GBP; L-34; gal3; Mac-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16854

Summary

Predicted to enable several functions, including IgE binding activity; advanced glycation end-product receptor activity; and signaling receptor binding activity. Involved in negative regulation of T cell receptor signaling pathway; negative regulation of endocytosis; and negative regulation of lymphocyte activation. Acts upstream of or within extracellular matrix organization and skeletal system development. Located in several cellular components, including external side of plasma membrane; glial cell projection; and immunological synapse. Is expressed in several structures, including alimentary system; genitourinary system; respiratory system; skeleton; and skin. Used to study fatty liver disease. Human ortholog(s) of this gene implicated in asthma. Orthologous to human LGALS3 (Galectin 3). [provided by Alliance of Genome Resources, Apr 2022]

Lgals3 Products (2)

mRNA Protein Name
NM_001145953.1 NP_001139425.1 galectin-3
NM_010705.3 NP_034835.1 galectin-3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10745073 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within extracellular matrix organization IGI
IGI: Inferred from genetic interaction
15800063 MGI
NOT involved in maintenance of protein location IDA
IDA: Inferred from direct assay
21670307 MGI
involved in negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IMP
IMP: Inferred from mutant phenotype
19706535 MGI
involved in negative regulation of T cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
19706535 MGI
involved in negative regulation of endocytosis IMP
IMP: Inferred from mutant phenotype
19706535 MGI
involved in negative regulation of immunological synapse formation IMP
IMP: Inferred from mutant phenotype
19706535 MGI
acts upstream of or within skeletal system development IGI
IGI: Inferred from genetic interaction
15800063 MGI
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
23576987 MGI
is active in cornified envelope IDA
IDA: Inferred from direct assay
26644517 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
10745073 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
23460747 MGI
located in extracellular matrix IDA
IDA: Inferred from direct assay
15800063 MGI
located in glial cell projection IDA
IDA: Inferred from direct assay
20826656 MGI
located in immunological synapse IDA
IDA: Inferred from direct assay
19706535 MGI
located in nucleus IDA
IDA: Inferred from direct assay
10745073 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

galectin-3

  • 35 kDa lectin

  • CBP 35

  • L-34 galactoside-binding lectin

  • carbohydrate-binding protein 35

  • gal-3

  • galactose-specific lectin 3

  • igE-binding protein

  • laminin-binding protein

  • lectin L-29

  • mac-2 antigen

Recombinant Lgals3 Proteins

Cat. No. Product Name Accession Purity
HY-P77684 Galectin-3/LGALS3 Protein, Mouse (HEK293, His) P16110 (A2-I264) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P79079 Galectin-3/LGALS3 Protein, Mouse NP_034835.1 (A2-I264) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07604 LGALS3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07605 LGALS3BP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16882 Lgals3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19847 Lgals3bp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23324 Lgals3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26345 Lgals3bp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992257 Anti-LGALS3BP Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lgals3 NCBI NCBI:3958