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Lgals9 - lectin, galactose binding, soluble 9 Gene

Also Known as gal-9; Lgals5; LGALS35; galectin-9

Species: Mus musculus

Gene Type: protein coding

Gene ID: 16859

Summary

Enables several functions, including carbohydrate binding activity; galactoside binding activity; and protein serine/threonine kinase activator activity. Involved in several processes, including regulation of cytokine production; regulation of defense response; and regulation of leukocyte activation. Located in cytoplasm and nucleus. Is expressed in several structures, including cardiovascular system; hemolymphoid system; intestine; liver; and metanephros. Orthologous to several human genes including LGALS9 (Galectin 9). [provided by Alliance of Genome Resources, Apr 2022]

Lgals9 Products (2)

mRNA	Protein	Name
NM_001159301.1	NP_001152773.1	galectin-9 isoform 2
NM_010708.2	NP_034838.2	galectin-9 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables carbohydrate binding	IDA IDA: Inferred from direct assay	23242525	MGI
enables carbohydrate binding	IMP IMP: Inferred from mutant phenotype	21670307	MGI
enables enzyme binding	IPI IPI: Inferred from physical interaction	21670307	MGI
enables galactoside binding	IMP IMP: Inferred from mutant phenotype	25065622	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16286920	MGI
enables protein serine/threonine kinase activator activity	IDA IDA: Inferred from direct assay	25065622	MGI
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	25065622	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to virus	IMP IMP: Inferred from mutant phenotype	23408620	MGI
involved in female pregnancy	IDA IDA: Inferred from direct assay	23242525	MGI
involved in maintenance of protein location	IDA IDA: Inferred from direct assay	21670307	MGI
involved in negative regulation of CD4-positive, alpha-beta T cell proliferation	IMP IMP: Inferred from mutant phenotype	25065622	MGI
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23408620	MGI
involved in negative regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	25065622	MGI
involved in negative regulation of natural killer cell activation	IMP IMP: Inferred from mutant phenotype	23408620	MGI
involved in negative regulation of natural killer cell degranulation	IMP IMP: Inferred from mutant phenotype	23408620	MGI
involved in negative regulation of type II interferon production	IDA IDA: Inferred from direct assay	23242525	MGI
involved in negative regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	23408620	MGI
involved in positive regulation of SMAD protein signal transduction	IMP IMP: Inferred from mutant phenotype	25065622	MGI
involved in positive regulation of T cell migration	IDA IDA: Inferred from direct assay	21670307	MGI
involved in positive regulation of chemokine production	IMP IMP: Inferred from mutant phenotype	20937702	MGI
involved in positive regulation of cytokine production	IMP IMP: Inferred from mutant phenotype	20937702	MGI
involved in positive regulation of defense response to bacterium	IMP IMP: Inferred from mutant phenotype	20937702	MGI
involved in positive regulation of innate immune response	IMP IMP: Inferred from mutant phenotype	20937702	MGI
involved in positive regulation of interleukin-1 production	IMP IMP: Inferred from mutant phenotype	20937702	MGI
involved in positive regulation of interleukin-10 production	IMP IMP: Inferred from mutant phenotype	25065622	MGI
involved in positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	25158758	MGI
involved in positive regulation of macrophage activation	IMP IMP: Inferred from mutant phenotype	20937702	MGI
involved in positive regulation of oxidoreductase activity	IDA IDA: Inferred from direct assay	21670307	MGI
involved in positive regulation of regulatory T cell differentiation	IMP IMP: Inferred from mutant phenotype	25065622	MGI
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	25158758	MGI
involved in receptor clustering	IDA IDA: Inferred from direct assay	25065622	MGI
NOT involved in regulation of T cell chemotaxis	IDA IDA: Inferred from direct assay	21670307	MGI
NOT involved in regulation of T cell differentiation in thymus	IMP IMP: Inferred from mutant phenotype	25065622	MGI
NOT involved in regulation of T-helper 17 type immune response	IMP IMP: Inferred from mutant phenotype	25065622	MGI
involved in regulation of natural killer cell differentiation	IMP IMP: Inferred from mutant phenotype	23408620	MGI
involved in response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	25158758	MGI
involved in transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	25065622	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	23242525	MGI
located in nucleus	IDA IDA: Inferred from direct assay	23242525	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
galectin-9	lectin, galactose binding, soluble 5

Recombinant Lgals9 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72637	Galectin-9/LGALS9 Protein, Mouse (GST)	O08573-2 (M1-T322)	≥ 85%, as determined by reducing SDS-PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS23307	Lgals9 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07610	LGALS9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07611	LGALS9B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16866	Lgals9 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992366	HFB200901	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lgals9	NCBI	NCBI:3965