Lmnb1 - lamin B1 Gene

Enables Phospholipase binding activity and sequence-specific double-stranded DNA binding activity. Predicted to be involved in cellular response to monosodium L-glutamate. Located in nuclear inner membrane and nuclear lumen. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; musculoskeletal system; and neural retina. Used to study adult-onset autosomal dominant demyelinating leukodystrophy. Human ortholog(s) of this gene implicated in adult-onset autosomal dominant demyelinating leukodystrophy and primary autosomal recessive microcephaly. Orthologous to human LMNB1 (lamin B1). [provided by Alliance of Genome Resources, Apr 2022]