Lum - lumican Gene

Also Known as Ldc; SLRR2D

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17022

Summary

Predicted to enable Collagen binding activity. Involved in positive regulation of transforming growth factor beta1 production. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in extracellular matrix. Is expressed in several structures, including alimentary system; ear; genitourinary system; heart and pericardium; and nervous system. Used to study Ehlers-Danlos syndrome classic type 1. Human ortholog(s) of this gene implicated in carotid artery disease; coronary artery disease; and pancreatic Cancer. Orthologous to human LUM (lumican). [provided by Alliance of Genome Resources, Apr 2022]

Lum Products (1)

mRNA Protein Name
NM_008524.2 NP_032550.2 lumican precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15849191 MGI
involved in positive regulation of transforming growth factor beta1 production IMP
IMP: Inferred from mutant phenotype
21931815 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular matrix IDA
IDA: Inferred from direct assay
12128073 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lumican

  • KSPG lumican

  • keratan sulfate proteoglycan lumican

Recombinant Lum Proteins

Cat. No. Product Name Accession Purity
HY-P70370 Lumican/LUM Protein, Mouse (HEK293, His) P51885 (Q19-N338) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16747 Maralixibat chloride Inhibitor 99.61% Unkown

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-101190 Volixibat 99.76% Phase 2
HY-163539A Pegulicianine / Phase 2

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-101190A (3R,4S,5S)-Volixibat 99.14% Unkown
HY-RS07891 LUM Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17525 Lum Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23982 Lum Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lum NCBI NCBI:4060