Lcn2 - lipocalin 2 Gene

Also Known as Sip24

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 170496

Summary

Enables enterobactin binding activity; identical protein binding activity; and protease binding activity. Involved in several processes, including cellular response to cytokine stimulus; memory; and regulation of neuron apoptotic process. Located in cytosol and extracellular space. Used to study intrahepatic cholangiocarcinoma and retinal degeneration. Biomarker of several diseases, including acute kidney failure; congenital diaphragmatic hernia; obesity; pulmonary hypertension; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in urinary tract Infection. Orthologous to human LCN2 (lipocalin 2). [provided by Alliance of Genome Resources, Apr 2022]

Lcn2 Products (1)

mRNA Protein Name
NM_130741.1 NP_570097.1 neutrophil gelatinase-associated lipocalin precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables enterobactin binding IPI
IPI: Inferred from physical interaction
26004810 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
17148685 RGD
enables protease binding IPI
IPI: Inferred from physical interaction
17148685 RGD
Biological Process GO Annotation Evidence References Source
involved in acute-phase response IEP
IEP: Inferred from expression pattern
22249220 RGD
involved in cellular response to X-ray IEP
IEP: Inferred from expression pattern
23331620 RGD
involved in cellular response to amyloid-beta IEP
IEP: Inferred from expression pattern
24853299 RGD
involved in cellular response to hydrogen peroxide IDA
IDA: Inferred from direct assay
19129400 RGD
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
24916903 RGD
involved in cellular response to increased oxygen levels IEP
IEP: Inferred from expression pattern
24916903 RGD
involved in cellular response to interleukin-1 IEP
IEP: Inferred from expression pattern
19329498 RGD
involved in cellular response to interleukin-6 IEP
IEP: Inferred from expression pattern
22249220 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
19329498 RGD
involved in cellular response to nerve growth factor stimulus IEP
IEP: Inferred from expression pattern
25412834 RGD
involved in cellular response to nutrient levels IEP
IEP: Inferred from expression pattern
17356516 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
19329498 RGD
involved in long-term memory IMP
IMP: Inferred from mutant phenotype
32174475 RGD
involved in negative regulation of hippocampal neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
32174475 RGD
involved in positive regulation of apoptotic process IGI
IGI: Inferred from genetic interaction
26013918 RGD
involved in positive regulation of cell projection organization IDA
IDA: Inferred from direct assay
19129400 RGD
involved in positive regulation of endothelial cell migration IDA
IDA: Inferred from direct assay
25557118 RGD
involved in positive regulation of endothelial tube morphogenesis IDA
IDA: Inferred from direct assay
25557118 RGD
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
19860839 RGD
involved in positive regulation of hippocampal neuron apoptotic process IDA
IDA: Inferred from direct assay
26004810 RGD
involved in positive regulation of iron ion import across plasma membrane IDA
IDA: Inferred from direct assay
25557118 RGD
involved in positive regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
30574656 RGD
involved in positive regulation of reactive oxygen species biosynthetic process IDA
IDA: Inferred from direct assay
25557118 RGD
involved in positive regulation of reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
30574656 RGD
involved in response to bacterium IEP
IEP: Inferred from expression pattern
19303090 RGD
involved in response to blue light IEP
IEP: Inferred from expression pattern
30574656 RGD
involved in response to fructose IEP
IEP: Inferred from expression pattern
24587658 RGD
involved in response to herbicide IDA
IDA: Inferred from direct assay
19129400 RGD
involved in response to iron(II) ion IEP
IEP: Inferred from expression pattern
23416150 RGD
involved in response to kainic acid IEP
IEP: Inferred from expression pattern
26004810 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
26004810 RGD
involved in response to mycotoxin IEP
IEP: Inferred from expression pattern
18308701 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
19221211 RGD
involved in response to oxidative stress IEP
IEP: Inferred from expression pattern
17553663 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
22366155 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
20043115 RGD
involved in response to xenobiotic stimulus IMP
IMP: Inferred from mutant phenotype
19860839 RGD
involved in short-term memory IMP
IMP: Inferred from mutant phenotype
32174475 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
20057160 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neutrophil gelatinase-associated lipocalin

  • NGAL

  • alpha-2-microglobulin-related protein

  • alpha-2U globulin-related protein

  • lipocalin 2 (oncogene 24p3)

  • lipocalin 24p3

  • p25

  • siderocalin LCN2

Recombinant Lcn2 Proteins

Cat. No. Product Name Accession Purity
HY-P74774 Lipocalin-2/NGAL Protein, Rat (sf9, His) P30152 (Q21-N198) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-Q45780 ZINC00640089 99.95% Unkown
HY-148364 ZINC00784494 Inhibitor 99.96% Unkown
HY-RS07557 LCN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-164959 ZINC00230567 Inhibitor 99.69% Unkown
HY-RS16572 Lcn2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-132195 RORγt inverse agonist 14 Inhibitor / Unkown
HY-158049 Anticancer agent 199 Inducer / Unkown
HY-RS23005 Lcn2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lcn2 NCBI NCBI:3934