Ly96 - lymphocyte antigen 96 Gene

Also Known as MD2; MD-2; ESOP-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17087

Summary

Predicted to enable lipopolysaccharide immune receptor activity. Involved in lipopolysaccharide-mediated signaling pathway; positive regulation of tumor necrosis factor production; and Toll-like Receptor 4 signaling pathway. Acts upstream of or within positive regulation of lipopolysaccharide-mediated signaling pathway. Part of lipopolysaccharide receptor complex. Is expressed in several structures, including extraembryonic component; gonad; immune system; integumental system; and nervous system. Orthologous to human LY96 (lymphocyte antigen 96). [provided by Alliance of Genome Resources, Apr 2022]

Ly96 Products (2)

mRNA Protein Name
NM_001159711.1 NP_001153183.1 lymphocyte antigen 96 isoform B precursor
NM_016923.2 NP_058619.1 lymphocyte antigen 96 isoform A precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17803912 MGI
Biological Process GO Annotation Evidence References Source
involved in cellular response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
24380872 MGI
acts upstream of lipopolysaccharide-mediated signaling pathway IDA
IDA: Inferred from direct assay
10880523 MGI
acts upstream of lipopolysaccharide-mediated signaling pathway IGI
IGI: Inferred from genetic interaction
10880523 MGI
involved in lipopolysaccharide-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
24380872 MGI
acts upstream of or within positive regulation of lipopolysaccharide-mediated signaling pathway IDA
IDA: Inferred from direct assay
10880523 MGI
acts upstream of or within positive regulation of lipopolysaccharide-mediated signaling pathway IGI
IGI: Inferred from genetic interaction
10880523 MGI
involved in positive regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
24380872 MGI
involved in toll-like receptor 4 signaling pathway IMP
IMP: Inferred from mutant phenotype
24380872 MGI
Cellular Component GO Annotation Evidence References Source
part of lipopolysaccharide receptor complex IDA
IDA: Inferred from direct assay
24380872 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lymphocyte antigen 96

  • ly-96

  • myeloid differentiation factor-2

  • myeloid differentiation protein-2

  • protein MD-2

Ly96 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Ly96 Q9JHF9 Tlr4 Mus musculus Q9QUK6
GMS
17803912
Intra
Ly96 Q9JHF9 Tlr4 Mus musculus Q9QUK6
X-Ray Diffraction
17803912
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Ly96 Proteins

Cat. No. Product Name Accession Purity
HY-P77081 MD-2/LY96 Protein, Mouse (HEK293, Fc) Q9JHF9 (E19-N160) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07908 LY96 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19614 Ly96 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26109 Ly96 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ly96 NCBI NCBI:23643