Opa1 - OPA1, mitochondrial dynamin like GTPase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 171116

Summary

Enables kinase binding activity. Involved in several processes, including mitochondrion organization; positive regulation of cellular component organization; and sensory organ development. Located in cytosol. Is extrinsic component of mitochondrial inner membrane. Colocalizes with mitochondrion. Used to study transient cerebral ischemia. Biomarker of several diseases, including artery disease (multiple); chronic kidney disease; fatty liver disease; ocular hypertension; and rhinitis. Human ortholog(s) of this gene implicated in Behr syndrome; dominant optic atrophy plus syndrome; mitochondrial DNA depletion syndrome 14; optic atrophy; and optic atrophy 1. Orthologous to human OPA1 (OPA1 mitochondrial Dynamin like GTPase). [provided by Alliance of Genome Resources, Apr 2022]

Opa1 Products (2)

mRNA Protein Name
NM_133585.3 NP_598269.3 dynamin-like 120 kDa protein, mitochondrial precursor
NM_133585.3 NP_598269.3 dynamin-like 120 kDa protein, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables kinase binding IPI
IPI: Inferred from physical interaction
23150663 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
20678484 RGD
Biological Process GO Annotation Evidence References Source
involved in calcium import into the mitochondrion IMP
IMP: Inferred from mutant phenotype
24085037 RGD
involved in cellular response to L-glutamate IEP
IEP: Inferred from expression pattern
28761318 RGD
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
27684054 RGD
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
27833818 RGD
involved in cochlea development IEP
IEP: Inferred from expression pattern
17828551 RGD
involved in intracellular distribution of mitochondria IMP
IMP: Inferred from mutant phenotype
19605646 RGD
involved in mitochondrion organization IDA
IDA: Inferred from direct assay
16778770 RGD
involved in mitochondrion organization IMP
IMP: Inferred from mutant phenotype
19605646 RGD
involved in positive regulation of cellular response to insulin stimulus IMP
IMP: Inferred from mutant phenotype
24085037 RGD
involved in positive regulation of dendrite development IMP
IMP: Inferred from mutant phenotype
23543485 RGD
involved in positive regulation of dendritic spine morphogenesis IMP
IMP: Inferred from mutant phenotype
19605646 RGD
involved in positive regulation of insulin receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
24085037 RGD
involved in positive regulation of mitochondrial fusion IMP
IMP: Inferred from mutant phenotype
22442078 RGD
involved in positive regulation of neuron maturation IMP
IMP: Inferred from mutant phenotype
23543485 RGD
involved in response to curcumin IEP
IEP: Inferred from expression pattern
27801955 RGD
involved in response to electrical stimulus IEP
IEP: Inferred from expression pattern
26513006 RGD
involved in response to muscle activity IEP
IEP: Inferred from expression pattern
28536949 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
25336449 RGD
involved in retina development in camera-type eye IEP
IEP: Inferred from expression pattern
15505078 RGD
Cellular Component GO Annotation Evidence References Source
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
16778770 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dynamin-like 120 kDa protein, mitochondrial

  • RN protein

  • mitochondrial OPA1

  • optic atrophy 1 (autosomal dominant)

  • optic atrophy 1 homolog

  • optic atrophy 1-like protein

  • optic atrophy protein 1 homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-126124 AP39 96.35% Unkown
HY-139109 IR-783 99.87% Unkown
HY-177306 Opitor-0 Inhibitor 98.02% Unkown
HY-158162 SIRT3 activator 1 Activator 98.14% Unkown
HY-116364B AZT triphosphate tetraammonium 99.25% Unkown
HY-RS16968 Opa1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-116364 AZT triphosphate / Unkown
HY-116364A AZT triphosphate TEA / Unkown
HY-RS08281 MED12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09789 OPA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-131037 MB-0223 Inhibitor / Unkown
HY-180786 DdBIC / Unkown
HY-RS18290 Med12 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23411 Opa1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Opa1 NCBI NCBI:4976