CAMK2G - calcium/calmodulin-dependent protein kinase II gamma Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 171140

About CAMK2G

Primary_assembly 15: 3,504,085-3,563,050 forward strand.mRatBN7.2:CM026988.1

This gene has 9 transcripts (splice variants), 297 orthologues, 21 paralogues and is associated with 4 phenotypes. Biased expression in Brain (RPKM 299.9), Muscle (RPKM 278.6) and 9 other tissues.

Summary

Enables calmodulin-dependent protein kinase activity. Involved in several processes, including protein autophosphorylation; regulation of protein localization to plasma membrane; and response to hypoxia. Predicted to be located in postsynaptic density. Predicted to be part of calcium- and calmodulin-dependent protein kinase complex. Predicted to be active in cytoplasm and neuron projection. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability. Orthologous to human CAMK2G (calcium/Calmodulin dependent protein kinase II gamma). [provided by Alliance of Genome Resources, Apr 2022]

CAMK2G Products (1)

mRNA	Protein	Name
NM_133605.1	NP_598289.1	calcium/calmodulin-dependent protein kinase type II subunit gamma

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium/calmodulin-dependent protein kinase activity	IDA IDA: Inferred from direct assay	11925434	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	11925434	RGD
involved in regulation of postsynaptic membrane neurotransmitter receptor levels	IDA IDA: Inferred from direct assay	35290589	RGD
involved in regulation of postsynaptic membrane neurotransmitter receptor levels	IMP IMP: Inferred from mutant phenotype	35290589	RGD
involved in regulation of protein localization to plasma membrane	IGI IGI: Inferred from genetic interaction	19188609	RGD
involved in response to hypoxia	IDA IDA: Inferred from direct assay	11925434	RGD
involved in response to oxidative stress	IDA IDA: Inferred from direct assay	11925434	RGD

Cellular Component GO Annotation	Evidence	References	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	35290589	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	35290589	RGD
is active in postsynaptic cytosol	IDA IDA: Inferred from direct assay	35290589	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAMK2G Protein Structure

STKc_CaMKII

CaMKII_AD

0
100
200
300
400
500
588 a.a.

Protein Preferred Names	Protein Names
calcium/calmodulin-dependent protein kinase type II subunit gamma	Ca+2/calmodulin-dependent protein kinase II gamma caM kinase II subunit gamma caM-kinase II gamma chain caMK-II subunit gamma calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma calcium/calmodulin-dependent protein kinase type II gamma chain calcium/calmodulin-dependent protein kinase type II subunit gamma-like

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01859	CAMK2G Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01860	Camk2g Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01861	CAMK2G Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	CAMK2G	NCBI	NCBI:818