Trpm4 - transient receptor potential cation channel, subfamily M, member 4 Gene

Also Known as Mls2s; LTrpC-4

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 171143

Summary

Enables calcium activated cation channel activity. Involved in several processes, including ion homeostasis; negative regulation of osteoblast differentiation; and regulation of blood circulation. Located in several cellular components, including Golgi apparatus; endoplasmic reticulum; and neuronal cell body. Biomarker of cardiac arrest. Human ortholog(s) of this gene implicated in erythrokeratodermia variabilis et progressiva 6 and progressive familial heart block type IB. Orthologous to human TRPM4 (transient receptor potential cation channel subfamily M member 4). [provided by Alliance of Genome Resources, Apr 2022]

Trpm4 Products (1)

mRNA	Protein	Name
NM_001136229.1	NP_001129701.1	transient receptor potential cation channel subfamily M member 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium-activated cation channel activity	IDA IDA: Inferred from direct assay	19945433	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	24114458	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in long-term memory	IMP IMP: Inferred from mutant phenotype	29971514	RGD
involved in negative regulation of bone mineralization	IMP IMP: Inferred from mutant phenotype	23081848	RGD
involved in negative regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	23081848	RGD
involved in positive regulation of adipose tissue development	IMP IMP: Inferred from mutant phenotype	23081848	RGD
involved in positive regulation of atrial cardiac muscle cell action potential	IMP IMP: Inferred from mutant phenotype	23954346	RGD
involved in positive regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	23081848	RGD
involved in positive regulation of fat cell differentiation	IMP IMP: Inferred from mutant phenotype	23081848	RGD
involved in positive regulation of heart rate	IMP IMP: Inferred from mutant phenotype	23954346	RGD
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	16806463	RGD
involved in positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization	IMP IMP: Inferred from mutant phenotype	20826763	RGD
involved in positive regulation of vasoconstriction	IMP IMP: Inferred from mutant phenotype	15472118	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	19945433	RGD
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	19945433	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	21848647	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	19945433	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
transient receptor potential cation channel subfamily M member 4	LTrpC4 calcium-activated non-selective cation channel 1 long transient receptor potential channel 4 melastatin like 2 protein melastatin-like 2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-128172	TRPM4-IN-2	Inhibitor	99.17%	Unkown
HY-108457	9-Phenanthrol	Inhibitor	99.61%	Unkown
HY-153468	ErSO-TFPy	Activator	99.33%	Unkown
HY-183268	TRPM4-IN-4	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Trpm4	NCBI	NCBI:54795