Smad1 - SMAD family member 1 Gene

Also Known as Mad1; Mlp1; Madh1; Madr1; dwf-A; mMad1; MusMLP

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17125

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding activity; and nucleic acid binding activity. Involved in several processes, including osteoblast differentiation; positive regulation of transcription by RNA polymerase II; and transmembrane receptor protein serine/threonine kinase signaling pathway. Acts upstream of or within several processes, including animal organ development; osteoblast fate commitment; and positive regulation of macromolecule metabolic process. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and sensory organ. Orthologous to human SMAD1 (Smad Family member 1). [provided by Alliance of Genome Resources, Apr 2022]

Smad1 Products (1)

mRNA Protein Name
NM_008539.4 NP_032565.2 mothers against decapentaplegic homolog 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
14633973 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
21976273 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
18692037 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
21724602 MGI
enables primary miRNA binding IDA
IDA: Inferred from direct assay
21145505 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12370310 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
23169531 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within BMP signaling pathway IDA
IDA: Inferred from direct assay
25100727 MGI
involved in BMP signaling pathway IDA
IDA: Inferred from direct assay
21976273 MGI
acts upstream of or within BMP signaling pathway IGI
IGI: Inferred from genetic interaction
16604073 MGI
involved in BMP signaling pathway IGI
IGI: Inferred from genetic interaction
19252488 MGI
acts upstream of or within BMP signaling pathway IMP
IMP: Inferred from mutant phenotype
15198985 MGI
acts upstream of or within MAPK cascade IMP
IMP: Inferred from mutant phenotype
15198985 MGI
involved in SMAD protein signal transduction IGI
IGI: Inferred from genetic interaction
19252488 MGI
acts upstream of or within bone development IGI
IGI: Inferred from genetic interaction
19224984 MGI
acts upstream of or within cardiac muscle cell proliferation IGI
IGI: Inferred from genetic interaction
17350578 MGI
acts upstream of or within cardiac muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
17350578 MGI
acts upstream of or within cartilage development IGI
IGI: Inferred from genetic interaction
19224984 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
15899870 MGI
acts upstream of or within cellular response to organic cyclic compound IDA
IDA: Inferred from direct assay
19103752 MGI
acts upstream of or within gamete generation IMP
IMP: Inferred from mutant phenotype
15198985 MGI
acts upstream of or within hindbrain development IMP
IMP: Inferred from mutant phenotype
15899870 MGI
acts upstream of or within homeostatic process IMP
IMP: Inferred from mutant phenotype
15198985 MGI
involved in inflammatory response IEP
IEP: Inferred from expression pattern
12151307 MGI
acts upstream of or within mesodermal cell fate commitment IGI
IGI: Inferred from genetic interaction
16801560 MGI
acts upstream of or within midbrain development IMP
IMP: Inferred from mutant phenotype
15899870 MGI
acts upstream of or within negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
15899870 MGI
involved in negative regulation of muscle cell differentiation IDA
IDA: Inferred from direct assay
21976273 MGI
involved in osteoblast differentiation IDA
IDA: Inferred from direct assay
7798324 MGI
acts upstream of or within osteoblast fate commitment IGI
IGI: Inferred from genetic interaction
15150273 MGI
acts upstream of or within positive regulation of cartilage development IDA
IDA: Inferred from direct assay
19251704 MGI
acts upstream of or within positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
18622394 MGI
involved in positive regulation of miRNA transcription IMP
IMP: Inferred from mutant phenotype
21145505 MGI
acts upstream of or within positive regulation of osteoblast differentiation IGI
IGI: Inferred from genetic interaction
15150273 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15557274 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
24211589 MGI
involved in positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
20843790 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
34995814 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
18776146 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12270938 MGI
acts upstream of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
18997172 MGI
involved in ureteric bud development IEP
IEP: Inferred from expression pattern
14656760 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11160896 MGI
part of homomeric SMAD protein complex IPI
IPI: Inferred from physical interaction
20147459 MGI
is active in nucleus IDA
IDA: Inferred from direct assay
21976273 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12151307 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
14633973 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mothers against decapentaplegic homolog 1

  • MAD homolog 1

  • dwarfin-A

  • mad-related protein 1

  • mothers against DPP homolog 1

  • mothers-against-DPP-related 1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-112499 Menaquinone-7 Activator 98.51% Phase 2

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P5542 Vicatertide Inhibitor 99.24% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Smad1 NCBI NCBI:4086