Havcr2 - hepatitis A virus cellular receptor 2 Gene

Also Known as Tim3; TIM-3; Timd3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 171285

Summary

Predicted to enable metal ion binding activity. Involved in several processes, including regulation of cytokine production; regulation of leukocyte activation; and Toll-like Receptor signaling pathway. Located in cell surface; early endosome; and immunological synapse. Is expressed in several structures, including dorsal aorta; gut; liver; lung; and reproductive system. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and renal cell carcinoma. Orthologous to human HAVCR2 (hepatitis A virus cellular receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Havcr2 Products (1)

mRNA Protein Name
NM_134250.2 NP_599011.2 hepatitis A virus cellular receptor 2 homolog precursor
Protein Preferred Names Protein Names

hepatitis A virus cellular receptor 2 homolog

  • HAVcr-2

  • T-cell immunoglobulin and mucin domain containing 3

  • T-cell immunoglobulin and mucin domain-containing protein 3

  • T-cell immunoglobulin mucin receptor 3

  • T-cell membrane protein 3

  • TIMD-3

Havcr2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Havcr2 Q8VIM0 Lgals9 Mus musculus O08573-2
Pull Down
16286920
Intra
Havcr2 Q8VIM0 Hmgb1 Mus musculus P63158
Confocal
22842346
Intra
Havcr2 Q8VIM0 Hmgb1 Mus musculus P63158
ELISA
22842346
Intra
Havcr2 Q8VIM0 Hmgb1 Mus musculus P63158
Anti Tag CoIP
22842346
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Havcr2 Proteins

Cat. No. Product Name Accession Purity
HY-P70826 TIM-3/HAVCR2 Protein, Mouse (HEK293, Fc) Q8VIM0-1 (R20-R191) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P71995 TIM-3/HAVCR2 Protein, Mouse (HEK293, hFc) Q8VIM0-1 (R20-R191) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P72448 TIM-3/HAVCR2 Protein, Mouse (HEK293, His) Q8VIM0-1 (R20-R191) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (4)
Cat. No. Product Name Effect
Purity Phase
HY-P990085 Verzistobart Inhibitor 99.9% Phase 2
HY-P990701 Lomvastomig 99.9% Phase 2
HY-P991395 TQB2618 Inhibitor 97.51% Phase 2
HY-P991397 Sym023 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-147273 Fulimetibant Antagonist 99.60% Unkown
HY-RS06022 HAVCR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17115 Havcr2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23560 Havcr2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Havcr2 NCBI NCBI:84868