Smad5 - SMAD family member 5 Gene

Also Known as Dwf-C; Madh5; MusMLP; 1110051M15Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17129

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in SMAD protein signal transduction; cellular response to BMP stimulus; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including animal organ development; osteoblast fate commitment; and transmembrane receptor protein serine/threonine kinase signaling pathway. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; egg cylinder; embryo mesenchyme; and genitourinary system. Orthologous to human SMAD5 (Smad Family member 5). [provided by Alliance of Genome Resources, Apr 2022]

Smad5 Products (3)

mRNA Protein Name
NM_001164041.1 NP_001157513.1 mothers against decapentaplegic homolog 5
NM_001164042.1 NP_001157514.1 mothers against decapentaplegic homolog 5
NM_008541.3 NP_032567.1 mothers against decapentaplegic homolog 5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
22964636 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
18692037 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
11729207 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12370310 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within BMP signaling pathway IDA
IDA: Inferred from direct assay
18590716 MGI
acts upstream of or within BMP signaling pathway IGI
IGI: Inferred from genetic interaction
19224984 MGI
involved in BMP signaling pathway IGI
IGI: Inferred from genetic interaction
19252488 MGI
involved in SMAD protein signal transduction IGI
IGI: Inferred from genetic interaction
19252488 MGI
acts upstream of or within bone development IGI
IGI: Inferred from genetic interaction
19224984 MGI
acts upstream of or within cardiac muscle contraction IMP
IMP: Inferred from mutant phenotype
17456754 MGI
acts upstream of or within cartilage development IGI
IGI: Inferred from genetic interaction
19224984 MGI
acts upstream of or within cellular response to organic cyclic compound IDA
IDA: Inferred from direct assay
19103752 MGI
acts upstream of or within erythrocyte differentiation IMP
IMP: Inferred from mutant phenotype
15591122 MGI
acts upstream of or within germ cell development IMP
IMP: Inferred from mutant phenotype
11404080 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
22964636 MGI
acts upstream of or within osteoblast fate commitment IGI
IGI: Inferred from genetic interaction
15150273 MGI
acts upstream of or within positive regulation of osteoblast differentiation IGI
IGI: Inferred from genetic interaction
15150273 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15557274 MGI
involved in positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
20843790 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
18776146 MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway IDA
IDA: Inferred from direct assay
11376112 MGI
involved in ureteric bud development IEP
IEP: Inferred from expression pattern
14656760 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
19103752 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12151307 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mothers against decapentaplegic homolog 5

  • MAD homolog 5

  • Smad 5

  • dwarfin-C

  • mSmad5

  • mothers against DPP homolog 5

Recombinant Smad5 Proteins

Cat. No. Product Name Accession Purity
HY-P74539 SMAD5 Protein, Mouse (sf9, His-GST) P97454 (T2-S465) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P74540 SMAD5 Protein, Mouse (sf9) P97454 (T2-S465) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13396 SMAD5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20491 Smad5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26999 Smad5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Smad5 NCBI NCBI:4090