CLYBL - citramalyl-CoA lyase Gene

Also Known as CLB

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 171425

About CLYBL

Cytogenetic location: 13q32.3 Genomic coordinates (GRCh38): 13:99,606,690-99,909,444 (from NCBI)

This gene has 9 transcripts (splice variants) and 196 orthologues. Broad expression in kidney (RPKM 2.9), liver (RPKM 2.6) and 22 other tissues.

Summary

Enables (S)-citramalyl-CoA lyase activity; magnesium ion binding activity; and malate synthase activity. Involved in protein homotrimerization and regulation of cobalamin metabolic process. Predicted to be located in mitochondrion. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

CLYBL Products (9)

mRNA	Protein	Name
NM_001393355.1	NP_001380284.1	citramalyl-CoA lyase, mitochondrial isoform 2 precursor
NM_001393356.1	NP_001380285.1	citramalyl-CoA lyase, mitochondrial isoform 1 precursor
NM_001393357.1	NP_001380286.1	citramalyl-CoA lyase, mitochondrial isoform 1 precursor
NM_001393358.1	NP_001380287.1	citramalyl-CoA lyase, mitochondrial isoform 1 precursor
NM_001393359.2	NP_001380288.1	citramalyl-CoA lyase, mitochondrial isoform 1 precursor
NM_001393360.1	NP_001380289.1	citramalyl-CoA lyase, mitochondrial isoform 2 precursor
NM_001393361.1	NP_001380290.1	citramalyl-CoA lyase, mitochondrial isoform 2 precursor
NM_001393362.1	NP_001380291.1	citramalyl-CoA lyase, mitochondrial isoform 2 precursor
NM_206808.5	NP_996531.1	citramalyl-CoA lyase, mitochondrial isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables (S)-citramalyl-CoA lyase activity	IDA IDA: Inferred from direct assay	29056341	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	24334609	GOA
enables malate synthase activity	IDA IDA: Inferred from direct assay	24334609	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in protein homotrimerization	IDA IDA: Inferred from direct assay	29056341	GOA
involved in regulation of cobalamin metabolic process	IDA IDA: Inferred from direct assay	29056341	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLYBL Protein Structure

HpcH_HpaI

0
100
200
300
340 a.a.

Protein Preferred Names	Protein Names
citramalyl-CoA lyase, mitochondrial	(3S)-malyl-CoA thioesterase

Related Diseases

Diseases	Alias
Tinea Profunda	Deep Seated Dermatophytosis Granuloma Trichophyticum Majocchi'S Granuloma
Tinea Barbae	Dermatophytosis Of Beard
Penicilliosis
Peroxisomal Biogenesis Disorder	Zellweger Spectrum Disorders Peroxisome Biogenesis Disorder-Zellweger Syndrome Spectrum Disorders Of Peroxisome Biogenesis Zellweger Spectrum Zellweger Syndrome Spectrum Peroxisomal Biogenesis Disorders Pbd, Zss Pbd-Zsd Pbd-Zss Pbd-Zellweger Spectrum Disorder Peroxisomal Biogenesis Disorders, Zellweger Syndrome Spectrum Peroxisome Biogenesis Disorder Peroxisome Biogenesis Disorder Spectrum Peroxisome Biogenesis Disorders Zellweger Spectrum Disorder Hyperpipecolic Acidaemia
Zellweger Syndrome	Cerebrohepatorenal Syndrome Zellweger Leukodystrophy Zs Congenital Iron Overload Chr Zws Severe Pbd-Zsd Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02852	CLYBL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CLYBL	VGNC	VGNC:60992
Mus musculus	CLYBL	MGD	MGI:1916884
Rattus norvegicus	CLYBL	RGD	RGD:1304615
Canis familiaris	CLYBL	VGNC	VGNC:39374
Macaca mulatta	CLYBL	VGNC	VGNC:71202
Bos taurus	CLYBL	VGNC	VGNC:27475
Others	CLYBL	NCBI