Mapkapk5 - MAP kinase-activated protein kinase 5 Gene

Also Known as MK5; PRAK

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17165

Summary

Enables mitogen-activated protein kinase binding activity; p53 binding activity; and protein serine/threonine kinase activity. Involved in Ras protein signal transduction; negative regulation of TOR signaling; and stress-induced premature senescence. Acts upstream of or within positive regulation of dendritic spine development. Located in cytoplasm; nucleus; and septin Cytoskeleton. Part of protein-containing complex. Is expressed in brain; embryo; and lung. Orthologous to human MAPKAPK5 (MAPK activated protein kinase 5). [provided by Alliance of Genome Resources, Apr 2022]

Mapkapk5 Products (1)

mRNA Protein Name
NM_010765.2 NP_034895.1 MAP kinase-activated protein kinase 5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables mitogen-activated protein kinase binding IPI
IPI: Inferred from physical interaction
15577943 MGI
enables p53 binding IDA
IDA: Inferred from direct assay
17254968 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15538386 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
15538386 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
15577943 MGI
Biological Process GO Annotation Evidence References Source
involved in Ras protein signal transduction IMP
IMP: Inferred from mutant phenotype
17254968 MGI
involved in negative regulation of TOR signaling IDA
IDA: Inferred from direct assay
21336308 MGI
acts upstream of or within positive regulation of dendritic spine development IGI
IGI: Inferred from genetic interaction
22508986 MGI
acts upstream of or within positive regulation of dendritic spine development IMP
IMP: Inferred from mutant phenotype
22508986 MGI
involved in stress-induced premature senescence IMP
IMP: Inferred from mutant phenotype
17254968 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15538386 MGI
located in nucleus IDA
IDA: Inferred from direct assay
15538386 MGI
part of protein-containing complex IDA
IDA: Inferred from direct assay
22508986 MGI
located in septin cytoskeleton IDA
IDA: Inferred from direct assay
22508986 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

MAP kinase-activated protein kinase 5

  • MAPK-activated protein kinase 5

  • MAPKAP kinase 5

  • MAPKAPK-5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-136848 SM1-71 Inhibitor 96.09% Unkown
HY-148062 RSS0680 Degrader 99.85% Unkown
HY-RS08135 MAPKAPK5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W782935 MAPKAPK5-IN-1 / Unkown
HY-RS17135 Mapkapk5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23581 Mapkapk5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mapkapk5 NCBI NCBI:8550