MAPKAPK5 - MAPK activated protein kinase 5 Gene
Also Known as MK5; MK-5; NCFD; PRAK; MAPKAP-K5
Species: Homo sapiens
About MAPKAPK5
This gene has 10 transcripts (splice variants), 178 orthologues, 6 paralogues and is associated with 2 phenotypes. Ubiquitous expression in small intestine (RPKM 3.1), colon (RPKM 2.9) and 25 other tissues.
Summary
The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012]
MAPKAPK5 Products (11)
| mRNA | Protein | Name |
|---|---|---|
| NM_001371479.1 | NP_001358408.1 | MAP kinase-activated protein kinase 5 isoform 3 |
| NM_001371480.1 | NP_001358409.1 | MAP kinase-activated protein kinase 5 isoform 4 |
| NM_001371481.1 | NP_001358410.1 | MAP kinase-activated protein kinase 5 isoform 5 |
| NM_001371482.1 | NP_001358411.1 | MAP kinase-activated protein kinase 5 isoform 6 |
| NM_001371483.1 | NP_001358412.1 | MAP kinase-activated protein kinase 5 isoform 7 |
| NM_001371484.1 | NP_001358413.1 | MAP kinase-activated protein kinase 5 isoform 8 |
| NM_001371485.1 | NP_001358414.1 | MAP kinase-activated protein kinase 5 isoform 9 |
| NM_001371486.1 | NP_001358415.1 | MAP kinase-activated protein kinase 5 isoform 10 |
| NM_001371487.1 | NP_001358416.1 | MAP kinase-activated protein kinase 5 isoform 11 |
| NM_003668.4 | NP_003659.2 | MAP kinase-activated protein kinase 5 isoform 1 |
| NM_139078.3 | NP_620777.1 | MAP kinase-activated protein kinase 5 isoform 2 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables p53 binding |
IDA
IDA: Inferred from direct assay
|
17254968 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
17254968 | GOA |
| enables protein serine/threonine kinase activity |
EXP
EXP: Inferred from Experiment
|
17254968 | GOA |
| enables protein serine/threonine kinase activity |
IDA
IDA: Inferred from direct assay
|
17254968 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in Ras protein signal transduction |
IDA
IDA: Inferred from direct assay
|
17254968 | GOA |
| acts upstream of positive regulation of telomere maintenance |
IMP
IMP: Inferred from mutant phenotype
|
21531765 | GOA |
| involved in positive regulation of transcription by RNA polymerase II |
IMP
IMP: Inferred from mutant phenotype
|
21531765 | GOA |
| involved in protein autophosphorylation |
IDA
IDA: Inferred from direct assay
|
21329882 | GOA |
| involved in regulation of translation |
IDA
IDA: Inferred from direct assay
|
21329882 | GOA |
| involved in stress-induced premature senescence |
IDA
IDA: Inferred from direct assay
|
17254968 | GOA |
MAPKAPK5 Protein Structure
Pkinase: Protein kinase domain (25 - 304)
- 0
- 100
- 200
- 300
- 400
- 473 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
MAP kinase-activated protein kinase 5 |
|
MAPKAPK5 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
MAPKAPK5 | Q8IW41 | MAPK6 | Homo sapiens | Q16659 | 25416956 | |
|
Intra
|
MAPKAPK5 | Q8IW41 | MAPK6 | Homo sapiens | Q16659 | 33961781 | |
|
Intra
|
MAPKAPK5 | Q8IW41 | MAPK6 | Homo sapiens | Q16659 | 32707033 | |
|
Intra
|
MAPKAPK5 | Q8IW41 | MAPK6 | Homo sapiens | Q16659 | 21900206 | |
|
Intra
|
MAPKAPK5 | Q8IW41 | MAPK6 | Homo sapiens | Q16659 | 20936779 | |
|
Intra
|
MAPKAPK5 | Q8IW41 | HSPB1 | Homo sapiens | P04792 | 21575178 | |
|
Intra
|
MAPKAPK5 | Q8IW41 | TP53 | Homo sapiens | P04637 | 17254968 |
Recombinant MAPKAPK5 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P74621 | PRAK/MAPKAPK5 Protein, Human (sf9, His-GST) | Q8IW41-2/NP_003659.2 (M1-Q471) | ≥ 90%, as determined by reducing SDS-PAGE. |
MAPKAPK5 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P85333 | MAPKAPK5 Antibody (YA5025) | IHC-P, ELISA | Human |
| HY-P85333A | MAPKAPK5 Antibody (YA5025)(PBS only) | IHC-P, ELISA | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Neurocardiofaciodigital Syndrome |
|
|
| Dientamoebiasis |
|
|
| Glioblastoma Mesenchymal Subtype |
|
|
| Pulmonary Immaturity |
|
|
| Noonan Syndrome 1 |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Bos taurus | MAPKAPK5 | VGNC | VGNC:31230 |
| Rattus norvegicus | MAPKAPK5 | RGD | RGD:1564113 |
| Mus musculus | MAPKAPK5 | MGD | MGI:1333110 |
| Canis familiaris | MAPKAPK5 | VGNC | VGNC:43008 |
| Felis catus | MAPKAPK5 | VGNC | VGNC:68177 |
| Macaca mulatta | MAPKAPK5 | VGNC | VGNC:74655 |
| Others | MAPKAPK5 | NCBI |