1. Gene
  2. MAPKAPK5 - MAPK activated protein kinase 5 Gene

MAPKAPK5 - MAPK activated protein kinase 5 Gene

Homo sapiens

Also known as MK5; MK-5; NCFD; PRAK; MAPKAP-K5

Gene ID: 8550 | Gene type: protein coding

About MAPKAPK5

Cytogenetic location: 12q24.12-q24.13 Genomic coordinates (GRCh38): 12:111,842,228-111,902,222 (from NCBI)

This gene has 10 transcripts (splice variants), 178 orthologues, 6 paralogues and is associated with 2 phenotypes. Ubiquitous expression in small intestine (RPKM 3.1), colon (RPKM 2.9) and 25 other tissues.

Summary

The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012]

MAPKAPK5 Products(11)

mRNA Protein Name
NM_001371479.1 NP_001358408.1 MAP kinase-activated protein kinase 5 isoform 3
NM_001371480.1 NP_001358409.1 MAP kinase-activated protein kinase 5 isoform 4
NM_001371481.1 NP_001358410.1 MAP kinase-activated protein kinase 5 isoform 5
NM_001371482.1 NP_001358411.1 MAP kinase-activated protein kinase 5 isoform 6
NM_001371483.1 NP_001358412.1 MAP kinase-activated protein kinase 5 isoform 7
NM_001371484.1 NP_001358413.1 MAP kinase-activated protein kinase 5 isoform 8
NM_001371485.1 NP_001358414.1 MAP kinase-activated protein kinase 5 isoform 9
NM_001371486.1 NP_001358415.1 MAP kinase-activated protein kinase 5 isoform 10
NM_001371487.1 NP_001358416.1 MAP kinase-activated protein kinase 5 isoform 11
NM_003668.4 NP_003659.2 MAP kinase-activated protein kinase 5 isoform 1
NM_139078.3 NP_620777.1 MAP kinase-activated protein kinase 5 isoform 2

MAPKAPK5 Protein Structure

Pkinase

Pkinase: Protein kinase domain (25 - 304)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 473 a.a.
Protein Preferred Names Protein Names

MAP kinase-activated protein kinase 5

MAPKAP kinase 5

Recombinant MAPKAPK5 Proteins

Cat. No. Product Name Accession Purity
HY-P74621 PRAK/MAPKAPK5 Protein, Human (sf9, His-GST) Q8IW41-2/NP_003659.2 (M1-Q471) ≥95%

Related Diseases

Diseases Alias
Neurocardiofaciodigital Syndrome

NCFD

Dientamoebiasis

Intestinal Trichomoniasis

Glioblastoma Mesenchymal Subtype
Pulmonary Immaturity

Primary Atelectasis Of Newborn

Primary Atelectasis, In Perinatal Period

Primary Failure To Expand Terminal Respiratory Units

Immature Lungs

Primary Atelectasis

Pulmonary Immaturity Nos

Lung Lobe Hypoplasia, Associated With Short Gestation

Lung Nonexpansion

Premature Lungs

Pulmonary Hypoplasia Associated With Short Gestation

Failure Of Expansion Of Terminal Respiratory Units

Primary Atelectasis Of Fetus Or Newborn

Primary Atelectasis In Perinatal Period

Noonan Syndrome 1

Noonan Syndrome

NS1

Male Turner Syndrome

Female Pseudo-Turner Syndrome

Turner Phenotype With Normal Karyotype

Noonan Syndrome With Pigmented Villonodular Synovitis

Turner'S Phenotype, Karyotype Normal

Familial Turner Syndrome

Noonan'S Syndrome

Noonan-Ehmke Syndrome

Ns

Pseudo-Ullrich-Turner Syndrome

Turner Syndrome In Female With X Chromosome

Turner-Like Syndrome

Ullrich-Noonan Syndrome

Noonan-Like/Multiple Giant Cell Lesion Syndrome

Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

Pterygium Colli Syndrome

Noonan Syndrome, Type 1

Turner Syndrome, Male

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus MAPKAPK5 VGNC VGNC:31230
Rattus norvegicus MAPKAPK5 RGD RGD:1564113
Mus musculus MAPKAPK5 MGD MGI:1333110
Canis familiaris MAPKAPK5 VGNC VGNC:43008
Felis catus MAPKAPK5 VGNC VGNC:68177
Macaca mulatta MAPKAPK5 VGNC VGNC:74655
Others MAPKAPK5 NCBI