Meis1 - Meis homeobox 1 Gene

Also Known as Evi8; C530044H18Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17268

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in negative regulation of myeloid cell differentiation and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including angiogenesis; hemopoiesis; and lens morphogenesis in camera-type eye. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb bud; and sensory organ. Orthologous to human MEIS1 (Meis homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Meis1 Products (2)

mRNA Protein Name
NM_001193271.1 NP_001180200.1 homeobox protein Meis1 isoform B
NM_010789.3 NP_034919.1 homeobox protein Meis1 isoform A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
9343407 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
19799567 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
10373562 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
9315626 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
19268698 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9315626 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15634706 MGI
enables sequence-specific DNA binding IGI
IGI: Inferred from genetic interaction
17049510 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within angiogenesis IMP
IMP: Inferred from mutant phenotype
14713950 MGI
acts upstream of or within blood vessel morphogenesis IMP
IMP: Inferred from mutant phenotype
15882575 MGI
acts upstream of or within definitive hemopoiesis IMP
IMP: Inferred from mutant phenotype
15882575 MGI
acts upstream of or within hemopoiesis IMP
IMP: Inferred from mutant phenotype
14713950 MGI
acts upstream of or within lens morphogenesis in camera-type eye IMP
IMP: Inferred from mutant phenotype
14713950 MGI
acts upstream of or within locomotory behavior IMP
IMP: Inferred from mutant phenotype
24642863 MGI
acts upstream of or within megakaryocyte development IMP
IMP: Inferred from mutant phenotype
20203303 MGI
involved in negative regulation of myeloid cell differentiation IDA
IDA: Inferred from direct assay
11438208 MGI
acts upstream of or within negative regulation of neuron differentiation IGI
IGI: Inferred from genetic interaction
18164701 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19799567 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12183364 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
9315626 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
9343407 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homeobox protein Meis1

  • myeloid ecotropic viral integration site 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (25)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15227 EPZ004777 99.74% Unkown
HY-156794 Enzomenib Inhibitor 99.88% Unkown
HY-134258 MEISi-1 Inhibitor 98.16% Unkown
HY-15222 Menin-MLL inhibitor MI-2 99.41% Unkown
HY-15227A EPZ004777 hydrochloride 98.92% Unkown
HY-134259 MEISi-2 Inhibitor 98.97% Unkown
HY-132870 MEIS-IN-2 Inhibitor 99.33% Unkown
HY-172416 Balomenib Inhibitor 99.81% Unkown
HY-155797 (S)-Bleximenib 96.06% Unkown
HY-RS08325 MEIS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-156794A Enzomenib enantiomer Inhibitor 98.01% Unkown
HY-115619 EPZ004777 formate / Unkown
HY-122698 CCI-007 Activator 98.45% Unkown
HY-15222A Menin-MLL inhibitor MI-2 dihydrochloride / Unkown
HY-155526 FY-21 Inhibitor / Unkown
HY-160018 BAY-155 Inhibitor / Unkown
HY-160733 Menin-MLL-IN-32 Inhibitor / Unkown
HY-178172 AF9/ENL-DOT1L PPI-IN-1 Inhibitor / Unkown
HY-RS08319 MEI1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-186043 Menin-MLL-IN-35 Inhibitor / Unkown
HY-186044 Menin-MLL-IN-36 Inhibitor / Unkown
HY-RS19217 Meis1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21374 Mei1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25706 Meis1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27893 Mei1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Meis1 NCBI NCBI:4211