MEIS1 - Meis homeobox 1 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4211

About MEIS1

Cytogenetic location: 2p14 Genomic coordinates (GRCh38): 2:66,435,125-66,573,869 (from NCBI)

This gene has 17 transcripts (splice variants), 215 orthologues and 12 paralogues. Ubiquitous expression in endometrium (RPKM 17.9), adrenal (RPKM 12.6) and 21 other tissues.

Summary

Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. [provided by RefSeq, Jul 2008]

MEIS1 Products (1)

mRNA Protein Name
NM_002398.3 NP_002389.1 homeobox protein Meis1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
26550823 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18692240 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MEIS1 Protein Structure

Homeobox_KN

Homeobox_KN: Homeobox KN domain (290 - 329)

  • 0
  • 100
  • 200
  • 300
  • 390 a.a.
Protein Preferred Names Protein Names

homeobox protein Meis1

  • Meis1, myeloid ecotropic viral integration site 1 homolog

MEIS1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MEIS1 O00470 TLX1 Homo sapiens P31314
Anti Tag CoIP
19559479
Intra
MEIS1 O00470 PBX1 Homo sapiens P40424
Y2H Array
20211142
Intra
MEIS1 O00470 PBX1 Homo sapiens P40424
Anti Tag CoIP
20541704
Intra
MEIS1 O00470 CREB1 Homo sapiens P16220
Anti Tag CoIP
20541704
Intra
MEIS1 O00470 CREB1 Homo sapiens P16220
CH-IP
20159610
Intra
MEIS1 O00470 ETS1 Homo sapiens P14921
Anti Bait CoIP
18692240
Cross: Cross-species interaction Intra: Intraspecies interaction

MEIS1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82693 MEIS1 Antibody (YA2438) WB, IP, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Restless Legs Syndrome

  • Wed

  • Willis-Ekbom Disease

  • Restless Leg Syndrome

  • Ekbom Syndrome

  • Wittmaack-Ekbom Syndrome

  • Willis Ekbom Disease

  • Ekbom'S Syndrome

  • Rls

  • Restless Legs

  • Restless Legs Syndrome, Susceptibility To
Myeloid Leukemia

  • Myeloid Leukaemia

  • Leukaemia Myelogenous

  • Leukemia Myelogenous

  • Myeloid Granulocytic Leukaemia

  • Myeloid Granulocytic Leukemia

  • Non-Lymphocytic Leukemia

  • Leukemia, Myeloid

  • Granulocytic Leukaemia

  • Myelogenous Leukaemia

  • Myeloid Leukaemia, Unspecified, Without Mention Of Remission
Restless Legs Syndrome 7

  • RLS7

  • Restless Legs Syndrome, Susceptibility To, 7
Fallopian Tube Adenosarcoma

  • Fallopian Tube Mullerian Adenosarcoma
Fallopian Tube Carcinosarcoma

  • Fallopian Tube Malignant Mixed Mesodermal Tumor

  • Fallopian Tube Malignant Mixed Mullerian Tumor
Acute Leukemia

  • Stem Cell Leukaemia

  • Stem Cell Leukemia

  • Acute Leukemias

  • Acute Undifferentiated Leukemia

  • Undifferentiated Leukemia

  • Acute Leukaemia Of Unspecified Cell Type Without Mention Of Remission

  • Blast Cell Leukaemia

  • Blast Leukaemia

  • Blastic Leukaemia

  • Undifferentiated Leukaemia
Leukemia

  • Leukemias

  • Leukaemia, Unspecified, Without Mention Of Remission

  • Aleukemic Leukaemia

  • Chronic Leukaemia

  • Subacute Leukaemia

  • Leukaemia Disorder

  • Leukaemia Nos
Acute Promyelocytic Leukemia

  • Leukemia, Acute Promyelocytic

  • Acute Myeloblastic Leukemia Type 3

  • Aml M3

  • APL

  • Leukemia, Acute Promyelocytic, Somatic

  • Aml With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Apml

  • Acute Myeloblastic Leukemia 3

  • Acute Myeloid Leukemia With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Acute Myeloblastic Leukaemia Type 3

  • Acute Myeloid Leukaemia M3

  • Acute Myeloid Leukemia M3

  • Acute Promyelocytic Leukaemia

  • M3 Anll

  • Myeloid Leukemia, Acute, M3

  • Leukemia Promyelocytic Acute

  • Leukemia, Promyelocytic, Acute

  • Leukemia, Acute, Promyelocytic
Leukemia, Acute Lymphoblastic

  • Acute Lymphoblastic Leukemia

  • ALL

  • Acute Lymphocytic Leukemia

  • Leukemia, Acute Lymphocytic, Susceptibility To, 1

  • Acute Lymphoblastic Leukaemia

  • Precursor Lymphoblastic Lymphoma/Leukemia

  • Precursor Lymphoid Neoplasm

  • Leukemia, Acute Lymphoblastic, Susceptibility To

  • B-Cell Acute Lymphoblastic Leukemia

  • Leukemia, Acute Lymphocytic 1

  • Acute Lymphocytic Leukaemia

  • Acute Lymphoblastic Leukemia/Lymphoma

  • All1

  • Childhood Acute Lymphoblastic Leukemia

  • Leukemia Acute Lymphoblastic 1

  • Leukemia Acute Lymphoblastic B-Hyperdiploid

  • Leukemia Acute Lymphocytic

  • Leukemia Acute Lymphocytic 1

  • Leukemia B-Cell Acute Lymphoblastic

  • Leukemia T-Cell Acute Lymphoblastic

  • Leukemia, Acute Lymphoblastic, 3

  • ALL3

  • Lymphoblastic Leukemia Acute

  • Leukemia, Acute, Lymphoblastic

  • Precursor Cell Lymphoblastic Leukemia Lymphoma

  • Leukemia, Lymphocytic, Acute, L1

  • Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Myelodysplastic Syndrome

  • Myelodysplastic Syndromes

  • Myelodysplasia

  • MDS

  • Myelodysplastic Syndrome Included

  • Myelodysplastic Syndrome, Susceptibility To, Included

  • Myelodysplastic Syndrome, Somatic

  • Myelodysplastic Syndrome, Susceptibility To
Leukemia, Chronic Myeloid

  • Chronic Myeloid Leukemia

  • Chronic Myelogenous Leukemia

  • CML

  • Chronic Granulocytic Leukemia

  • Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib

  • Chronic Myeloid Leukaemia

  • Chronic Granulocytic Leukaemia

  • Chronic Myelogenous Leukaemia

  • Myeloid Leukemia, Chronic

  • Leukemia, Chronic Myelogenous

  • Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic

  • Cml - Chronic Myelogenous Leukemia

  • Cgl

  • Chronic Myelocytic Leukemia

  • Leukemia, Chronic Myeloid, Atypical

  • ACML

  • Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative

  • Myeloid Leukemia Chronic

  • Leukemia, Myeloid, Chronic

  • Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative

  • Cml- [Chronic Myeloid Leukaemia]

  • Cgl - [Chronic Granulocytic Leukaemia]

  • Chronic Myelocytic Leukaemia
Leukemia, Acute Myeloid

  • Acute Myeloid Leukemia

  • Leukemia, Acute Myelogenous

  • Acute Myelogenous Leukemia

  • AML

  • Leukemia, Acute Myeloid, Susceptibility To

  • Acute Myeloblastic Leukemia

  • Leukemia, Acute Myeloid, Reduced Survival In, Somatic

  • Acute Myeloid Leukaemia

  • Leukemia, Myelocytic, Acute

  • Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

  • Secondary Aml

  • Acute Myelocytic Leukemia

  • Acute Myeloid Leukemia, Somatic

  • Leukemia, Acute Myeloid, Somatic

  • Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

  • Acute Myeloblastic Leukaemia

  • Acute Myelogenous Leukaemia

  • Aml - Acute Myeloid Leukemia

  • Acute Myeloid Leukemia With Cebpa Somatic Mutations

  • Aml With Cebpa Somatic Mutations

  • Inherited Acute Myeloid Leukemia

  • Familial Aml

  • Inherited Aml

  • Pure Familial Aml

  • Pure Familial Acute Myeloid Leukemia

  • Secondary Acute Myeloid Leukemia

  • Therapy-Related Aml And Myelodysplastic Syndrome

  • Acute Myeloid Leukemia, Secondary

  • Acute Non-Lymphoblastic Leukemia

  • Acute Non-Lymphocytic Leukemia

  • Acute Biphenotypic Leukemia

  • Acute Undifferentiated Leukemia

  • Acute Myeloblastic Leukaemia With Multilineage Dysplasia

  • Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

  • Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (25)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15227 EPZ004777 99.74% Unkown
HY-156794 Enzomenib Inhibitor 99.88% Unkown
HY-134258 MEISi-1 Inhibitor 98.16% Unkown
HY-15222 Menin-MLL inhibitor MI-2 99.41% Unkown
HY-15227A EPZ004777 hydrochloride 98.92% Unkown
HY-134259 MEISi-2 Inhibitor 98.97% Unkown
HY-132870 MEIS-IN-2 Inhibitor 99.33% Unkown
HY-172416 Balomenib Inhibitor 99.81% Unkown
HY-155797 (S)-Bleximenib 96.06% Unkown
HY-RS08325 MEIS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-156794A Enzomenib enantiomer Inhibitor 98.01% Unkown
HY-115619 EPZ004777 formate / Unkown
HY-122698 CCI-007 Activator 98.45% Unkown
HY-15222A Menin-MLL inhibitor MI-2 dihydrochloride / Unkown
HY-155526 FY-21 Inhibitor / Unkown
HY-160018 BAY-155 Inhibitor / Unkown
HY-160733 Menin-MLL-IN-32 Inhibitor / Unkown
HY-178172 AF9/ENL-DOT1L PPI-IN-1 Inhibitor / Unkown
HY-RS08319 MEI1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-186043 Menin-MLL-IN-35 Inhibitor / Unkown
HY-186044 Menin-MLL-IN-36 Inhibitor / Unkown
HY-RS19217 Meis1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21374 Mei1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25706 Meis1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27893 Mei1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus MEIS1 VGNC VGNC:31381
Felis catus MEIS1 VGNC VGNC:81120
Macaca mulatta MEIS1 VGNC VGNC:74701
Mus musculus MEIS1 MGD MGI:104717
Rattus norvegicus MEIS1 RGD RGD:1585482
Canis familiaris MEIS1 VGNC VGNC:43153
Others MEIS1 NCBI