Melk - maternal embryonic leucine zipper kinase Gene

Also Known as MPK38; mKIAA0175

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17279

About Melk

Chromosome 4: 44,300,876-44,364,675 forward strand.GRCm39:CM000997.3

This gene has 4 transcripts (splice variants), 217 orthologues, 19 paralogues and is associated with 1 phenotype. Biased expression in CNS E11.5 (RPKM 14.4), placenta adult (RPKM 9.4) and 14 other tissues.

Summary

Enables protein serine/threonine kinase activity. Involved in neural precursor cell proliferation and positive regulation of apoptotic process. Acts upstream of or within intrinsic apoptotic signaling pathway in response to oxidative stress. Located in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Orthologous to human MELK (maternal embryonic leucine zipper kinase). [provided by Alliance of Genome Resources, Apr 2022]

Melk Products (1)

mRNA Protein Name
NM_010790.2 NP_034920.2 maternal embryonic leucine zipper kinase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18948261 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
9305775 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
18948261 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within intrinsic apoptotic signaling pathway in response to oxidative stress IDA
IDA: Inferred from direct assay
18948261 MGI
involved in neural precursor cell proliferation IDA
IDA: Inferred from direct assay
16061694 MGI
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
18948261 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
10417823 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Melk Protein Structure

STKc_MELK

STKc_MELK: cd14078 (6 - 262)

UBA_MELK

UBA_MELK: cd14341 (280 - 331)

MELK_C

MELK_C: cd12198 (546 - 640)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 643 a.a.
Protein Preferred Names Protein Names

maternal embryonic leucine zipper kinase

  • protein kinase PK38

  • tyrosine-protein kinase MELK

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-15512 OTSSP167 Inhibitor 99.27% Phase 2
HY-15512A OTSSP167 hydrochloride Inhibitor 99.78% Phase 2

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100368A MELK-8a hydrochloride Inhibitor 99.31% Unkown
HY-148065 FMF-06-098-1 Inhibitor 98.77% Unkown
HY-101515 MELK-IN-1 Inhibitor 98.03% Unkown
HY-12420 JNJ-47117096 hydrochloride Inhibitor 99.67% Unkown
HY-122665 HTH-01-091 Inhibitor 99.81% Unkown
HY-100368 MELK-8a Inhibitor 98.32% Unkown
HY-122665A HTH-01-091 TFA Inhibitor 99.48% Unkown
HY-155748 Antitumor agent-116 Inhibitor / Unkown
HY-N17632 Moracin G Inhibitor / Unkown
HY-12420A JNJ-47117096 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Melk NCBI NCBI:9833