2. Gene
  3. Melk - maternal embryonic leucine zipper kinase Gene

Melk - maternal embryonic leucine zipper kinase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as MPK38; mKIAA0175

Gene ID: 17279 | Gene type: protein coding

About Melk

Chromosome 4: 44,300,876-44,364,675 forward strand.GRCm39:CM000997.3

This gene has 4 transcripts (splice variants), 217 orthologues, 19 paralogues and is associated with 1 phenotype. Biased expression in CNS E11.5 (RPKM 14.4), placenta adult (RPKM 9.4) and 14 other tissues.

Summary

Enables protein serine/threonine kinase activity. Involved in neural precursor cell proliferation and positive regulation of apoptotic process. Acts upstream of or within intrinsic apoptotic signaling pathway in response to oxidative stress. Located in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Orthologous to human MELK (maternal embryonic leucine zipper kinase). [provided by Alliance of Genome Resources, Apr 2022]

Melk Products(1)

mRNA Protein Name
NM_010790.2 NP_034920.2 maternal embryonic leucine zipper kinase

Melk Protein Structure

STKc_MELK

STKc_MELK: cd14078 (6 - 262)

UBA_MELK

UBA_MELK: cd14341 (280 - 331)

MELK_C

MELK_C: cd12198 (546 - 640)

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  • 643 a.a.
Protein Preferred Names Protein Names

maternal embryonic leucine zipper kinase

protein kinase PK38

tyrosine-protein kinase MELK

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-15512A OTSSP167 hydrochloride Inhibitor 99.84% Phase 2
HY-15512 OTSSP167 Inhibitor 99.70% Phase 2
Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12420 JNJ-47117096 hydrochloride Inhibitor 99.68% Unkown
HY-100368A MELK-8a hydrochloride Inhibitor 99.26% Unkown
HY-101515 MELK-IN-1 Inhibitor 98.67% Unkown
HY-122665 HTH-01-091 Inhibitor 98.64% Unkown
HY-122665A HTH-01-091 TFA Inhibitor 99.48% Unkown
HY-155748 Antitumor agent-116 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Melk NCBI NCBI:9833