Mlf1 - myeloid leukemia factor 1 Gene

Also Known as HLS7

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17349

Summary

Enables DNA binding activity. Involved in myeloid progenitor cell differentiation and transcription, DNA-templated. Located in several cellular components, including ciliary basal body; ciliary base; and non-motile cilium. Is expressed in several structures, including brain; gonad; immune system; lung; and nasal cavity respiratory epithelium. Orthologous to human MLF1 (myeloid leukemia factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Mlf1 Products (2)

mRNA Protein Name
NM_001039543.2 NP_001034632.1 myeloid leukemia factor 1 isoform a
NM_010801.3 NP_034931.2 myeloid leukemia factor 1 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
17008314 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12176995 MGI
Biological Process GO Annotation Evidence References Source
involved in DNA-templated transcription IDA
IDA: Inferred from direct assay
17008314 MGI
involved in myeloid progenitor cell differentiation IDA
IDA: Inferred from direct assay
10523300 MGI
Cellular Component GO Annotation Evidence References Source
located in ciliary basal body IDA
IDA: Inferred from direct assay
27914912 MGI
is active in ciliary base IDA
IDA: Inferred from direct assay
27914912 MGI
located in cilium IDA
IDA: Inferred from direct assay
27914912 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
12176995 MGI
located in motile cilium IDA
IDA: Inferred from direct assay
23300604 MGI
located in non-motile cilium IDA
IDA: Inferred from direct assay
23300604 MGI
located in nucleus IDA
IDA: Inferred from direct assay
17008314 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

myeloid leukemia factor 1

  • hematopoietic lineage switch 7

  • myelodysplasia-myeloid leukemia factor 1

Mlf1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Mlf1 Q9QWV4 Ywhaz Mus musculus P63101
Pull Down
12176995
Intra
Mlf1 Q9QWV4 Ywhaz Mus musculus P63101
Y2H
12176995
Intra
Mlf1 Q9QWV4 Nrbp1 Mus musculus Q99J45
Anti Tag CoIP
12176995
Intra
Mlf1 Q9QWV4 Nrbp1 Mus musculus Q99J45
Y2H
12176995
Intra
Mlf1 Q9QWV4 Nrbp1 Mus musculus Q99J45
IF
12176995
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08487 MLF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22237 Mlf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28759 Mlf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mlf1 NCBI NCBI:4291