Mmp16 - matrix metallopeptidase 16 Gene

Also Known as Mt3mmp; MT3-MMP; MT-MMP 3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17389

Summary

This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading Enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein exhibit retarded growth of the skeleton, especially in the cranium and long bones. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Mmp16 Products (3)

mRNA Protein Name
NM_001379518.1 NP_001366447.1 matrix metalloproteinase-16 preproprotein
NM_001379519.1 NP_001366448.1 matrix metalloproteinase-16 preproprotein
NM_019724.5 NP_062698.2 matrix metalloproteinase-16 preproprotein

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within bone development IGI
IGI: Inferred from genetic interaction
18022611 MGI
acts upstream of or within chondrocyte proliferation IGI
IGI: Inferred from genetic interaction
18022611 MGI
acts upstream of or within collagen catabolic process IDA
IDA: Inferred from direct assay
18022611 MGI
acts upstream of or within collagen catabolic process IGI
IGI: Inferred from genetic interaction
18022611 MGI
acts upstream of or within craniofacial suture morphogenesis IGI
IGI: Inferred from genetic interaction
18022611 MGI
acts upstream of or within embryonic cranial skeleton morphogenesis IGI
IGI: Inferred from genetic interaction
18022611 MGI
acts upstream of or within endochondral ossification IGI
IGI: Inferred from genetic interaction
18022611 MGI
acts upstream of or within ossification IGI
IGI: Inferred from genetic interaction
18022611 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

matrix metalloproteinase-16

  • Membrane type 3-MMP

  • membrane-type matrix metalloproteinase 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS22645 Mmp16 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29159 Mmp16 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08532 MMP16 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992267 Anti-MMP-16 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mmp16 NCBI NCBI:4325