Mpeg1 - macrophage expressed gene 1 Gene

Also Known as P-2; MPS1; Mpg-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17476

Summary

Involved in defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; and pore formation in membrane of Other organism. Located in phagocytic vesicle. Is expressed in several structures, including blood vessel; central nervous system; developing vasculature of reproductive system; and retina outer nuclear layer. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human MPEG1 (macrophage expressed 1). [provided by Alliance of Genome Resources, Apr 2022]

Mpeg1 Products (2)

mRNA Protein Name
NM_001374668.1 NP_001361597.1 macrophage-expressed gene 1 protein precursor
NM_010821.2 NP_034951.2 macrophage-expressed gene 1 protein precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables pore-forming activity IDA
IDA: Inferred from direct assay
26402460 MGI
enables wide pore channel activity IDA
IDA: Inferred from direct assay
32064340 MGI
Biological Process GO Annotation Evidence References Source
NOT involved in antibacterial innate immune response IMP
IMP: Inferred from mutant phenotype
35471730 MGI
involved in antibacterial innate immune response IMP
IMP: Inferred from mutant phenotype
26402460 MGI
involved in antigen processing and presentation of exogenous peptide antigen IDA
IDA: Inferred from direct assay
35471730 MGI
involved in antigen processing and presentation of exogenous peptide antigen via MHC class I IDA
IDA: Inferred from direct assay
37347855 MGI
involved in defense response to Gram-negative bacterium IMP
IMP: Inferred from mutant phenotype
23257510 MGI
involved in defense response to Gram-positive bacterium IMP
IMP: Inferred from mutant phenotype
23257510 MGI
involved in defense response to bacterium IMP
IMP: Inferred from mutant phenotype
26402460 MGI
involved in dendritic cell antigen processing and presentation IDA
IDA: Inferred from direct assay
37347855 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
26402460 MGI
is active in endolysosome IDA
IDA: Inferred from direct assay
35471730 MGI
located in phagocytic vesicle IDA
IDA: Inferred from direct assay
26402460 MGI
is active in phagocytic vesicle membrane IDA
IDA: Inferred from direct assay
37347855 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

macrophage-expressed gene 1 protein

  • macrophage gene 1 protein

  • perforin-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-114512 m-PEG1-NHS ester 95.0% Unkown
HY-RS08610 MPEG1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20991 Mpeg1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27508 Mpeg1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mpeg1 NCBI NCBI:219972