Mstn - myostatin Gene

Also Known as Cmpt; Gdf8

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17700

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein negatively regulates skeletal muscle cell proliferation and differentiation. Homozygous knockout mice for this gene exhibit increased muscle mass and bone density, and reduced adiposity. [provided by RefSeq, Jul 2016]

Mstn Products (1)

mRNA Protein Name
NM_010834.3 NP_034964.1 growth/differentiation factor 8 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables heparin binding IDA
IDA: Inferred from direct assay
19644449 MGI
enables identical protein binding IDA
IDA: Inferred from direct assay
28257634 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12595574 MGI
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
19644449 MGI
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
11459935 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to dexamethasone stimulus IDA
IDA: Inferred from direct assay
23752591 MGI
involved in myoblast migration involved in skeletal muscle regeneration IMP
IMP: Inferred from mutant phenotype
19406121 MGI
involved in negative regulation of insulin receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
16182246 MGI
involved in negative regulation of kinase activity IMP
IMP: Inferred from mutant phenotype
19357233 MGI
acts upstream of or within negative regulation of skeletal muscle tissue growth IMP
IMP: Inferred from mutant phenotype
18286185 MGI
involved in negative regulation of skeletal muscle tissue growth IMP
IMP: Inferred from mutant phenotype
9139826 MGI
involved in positive regulation of lamellipodium assembly IMP
IMP: Inferred from mutant phenotype
19406121 MGI
involved in positive regulation of macrophage chemotaxis IMP
IMP: Inferred from mutant phenotype
19406121 MGI
involved in skeletal muscle satellite cell differentiation IMP
IMP: Inferred from mutant phenotype
26923583 MGI
involved in skeletal muscle tissue regeneration IMP
IMP: Inferred from mutant phenotype
26923583 MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway IDA
IDA: Inferred from direct assay
12595574 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
12595574 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

growth/differentiation factor 8

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08731 MSTN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-183005 ActRIIB-IN-1 / Unkown
HY-183504 ActRIIB-IN-3 Inhibitor / Unkown
HY-RS18142 Mstn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24617 Mstn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mstn NCBI NCBI:2660