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Cat. No.: HY-183504

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ActRIIB-IN-3

ActRIIB-IN-3 is a ActRIIB inhibitor. ActRIIB-IN-3 inhibits the ActRIIB protein in the MSTN pathway and induces the reversal of skeletal muscle atrophy associated with cancer cachexia. ActRIIB-IN-3 is applicable for the research of cancer cachexia.

For research use only. We do not sell to patients.

CAS No.: 3039974-35-8
Formula: C₂₂H₂₄N₆
Molecular Weight:372.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

ActRIIB-IN-3 Chemical Structure

CAS No.: 3039974-35-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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- In Vitro
Chemical Information
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Biological Activity

Description

All TGF-β Receptor Isoforms :

In Vitro

ActRIIB-IN-3 (P43 Compound 6) inhibits the ActRIIB protein in the MSTN pathway and induces the reversal of skeletal muscle atrophy associated with cancer cachexia^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3039974-35-8
Molecular Weight 372.47
Formula C₂₂H₂₄N₆
SMILES

CN1N=CC=C1C2=CNC3=NC=C(C4=CC=C(N5CCN(CC5)C)C=C4)C=C32
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Dong Xiaochun, et al. 7-azaindole compounds, preparation method therefor, and use thereof. WO2024114661A1. 2025-06-01.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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- In Vitro
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Purity & Documentation
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ActRIIB-IN-3

All TGF-β Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

ActRIIB-IN-3 Related Classifications

HY-183504 Related Classifications