Map1a - microtubule-associated protein 1 A Gene

Also Known as Mtap1; moth1; Mtap-1; Mtap1a; 6330416M19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17754

Summary

Enables cytoskeletal anchor activity; cytoskeletal protein binding activity; and ionotropic glutamate receptor binding activity. Involved in several processes, including axo-dendritic protein transport; learning or memory; and negative regulation of protein localization to microtubule. Acts upstream of or within photoreceptor cell maintenance and sensory perception of sound. Located in several cellular components, including axon initial segment; dendritic microtubule; and photoreceptor outer segment. Is expressed in cerebral cortex marginal zone; cortical plate; cortical subplate; and spinal cord. Orthologous to human MAP1A (microtubule associated protein 1A). [provided by Alliance of Genome Resources, Apr 2022]

Map1a Products (2)

mRNA Protein Name
NM_001173506.1 NP_001166977.1 microtubule-associated protein 1A isoform 2
NM_032393.2 NP_115769.1 microtubule-associated protein 1A isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin binding IDA
IDA: Inferred from direct assay
26609151 MGI
enables cytoskeletal anchor activity IDA
IDA: Inferred from direct assay
26609151 MGI
enables ionotropic glutamate receptor binding IPI
IPI: Inferred from physical interaction
26609151 MGI
enables microtubule binding IDA
IDA: Inferred from direct assay
17360631 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11925566 MGI
enables tubulin binding IDA
IDA: Inferred from direct assay
26609151 MGI
Biological Process GO Annotation Evidence References Source
involved in anterograde axonal protein transport IGI
IGI: Inferred from genetic interaction
26609151 MGI
involved in associative learning IMP
IMP: Inferred from mutant phenotype
26609151 MGI
involved in memory IMP
IMP: Inferred from mutant phenotype
26609151 MGI
involved in microtubule cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
25788676 MGI
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
26609151 MGI
involved in negative regulation of protein localization to microtubule IMP
IMP: Inferred from mutant phenotype
25788676 MGI
involved in neuron cellular homeostasis IMP
IMP: Inferred from mutant phenotype
25788676 MGI
involved in neuron projection maintenance IMP
IMP: Inferred from mutant phenotype
25788676 MGI
acts upstream of or within photoreceptor cell maintenance IGI
IGI: Inferred from genetic interaction
22323461 MGI
involved in positive regulation of protein localization IMP
IMP: Inferred from mutant phenotype
26609151 MGI
involved in positive regulation of protein localization to cell surface IMP
IMP: Inferred from mutant phenotype
26609151 MGI
involved in regulation of synaptic plasticity IMP
IMP: Inferred from mutant phenotype
26609151 MGI
involved in retrograde axonal protein transport IGI
IGI: Inferred from genetic interaction
26609151 MGI
acts upstream of or within sensory perception of sound IDA
IDA: Inferred from direct assay
11925566 MGI
involved in voluntary musculoskeletal movement IMP
IMP: Inferred from mutant phenotype
25788676 MGI
Cellular Component GO Annotation Evidence References Source
located in axon initial segment IDA
IDA: Inferred from direct assay
25788676 MGI
located in cytosol IDA
IDA: Inferred from direct assay
11925566 MGI
located in dendrite IDA
IDA: Inferred from direct assay
25788676 MGI
located in dendritic microtubule IDA
IDA: Inferred from direct assay
25788676 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
25788676 MGI
located in photoreceptor outer segment IDA
IDA: Inferred from direct assay
24664738 MGI
located in postsynaptic density IDA
IDA: Inferred from direct assay
17114649 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

microtubule-associated protein 1A

  • MAP-1A

  • modifier of tubby hearing 1

  • short MAP1A

  • short microtubule-associated protein 1A

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08026 MAP1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08348 METAP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18394 Map1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24875 Map1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Map1a NCBI NCBI:4130