Myb - myeloblastosis oncogene Gene

Also Known as c-myb

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17863

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and WD40-repeat domain binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including cellular response to cytokine stimulus; embryonic digestive tract development; and hematopoietic or lymphoid organ development. Located in cytosol and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and sensory organ. Used to study essential thrombocythemia and myelofibrosis. Orthologous to human MYB (MYB proto-oncogene, transcription factor). [provided by Alliance of Genome Resources, Apr 2022]

Myb Products (2)

mRNA Protein Name
NM_001198914.1 NP_001185843.1 transcriptional activator Myb isoform 1
NM_010848.3 NP_034978.3 transcriptional activator Myb isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
12628004 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
12244173 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
12628004 MGI
enables DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
12660151 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
12244173 MGI
enables WD40-repeat domain binding IDA
IDA: Inferred from direct assay
16162816 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
8302594 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within B cell differentiation IMP
IMP: Inferred from mutant phenotype
17927961 MGI
acts upstream of or within G1/S transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
12660151 MGI
acts upstream of or within calcium ion transport IMP
IMP: Inferred from mutant phenotype
12660151 MGI
acts upstream of or within cellular response to interleukin-6 IDA
IDA: Inferred from direct assay
16162816 MGI
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
acts upstream of or within embryonic digestive tract development IMP
IMP: Inferred from mutant phenotype
10523863 MGI
acts upstream of or within homeostasis of number of cells IMP
IMP: Inferred from mutant phenotype
17927961 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
10523863 MGI
acts upstream of or within myeloid cell differentiation IMP
IMP: Inferred from mutant phenotype
19360001 MGI
involved in positive regulation of transcription by RNA polymerase II EXP
EXP: Inferred from Experiment
11792321 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12244173 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
15094381 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12628004 MGI
acts upstream of or within regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
12660151 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
10523863 MGI
acts upstream of or within spleen development IMP
IMP: Inferred from mutant phenotype
19360001 MGI
acts upstream of or within stem cell division IMP
IMP: Inferred from mutant phenotype
19360001 MGI
acts upstream of or within thymus development IMP
IMP: Inferred from mutant phenotype
17927961 MGI
Cellular Component GO Annotation Evidence References Source
part of RNA polymerase II transcription regulator complex EXP
EXP: Inferred from Experiment
11792321 MGI
located in cytosol IDA
IDA: Inferred from direct assay
16162816 MGI
located in nucleus IDA
IDA: Inferred from direct assay
8302594 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcriptional activator Myb

  • gag-myb protein

  • myb proto-oncogene protein

  • myeloblastosis proto-oncogene product

  • proto-oncogene c-Myb

  • tumor-specific myb protein

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-108634 Apafant Antagonist 99.96% Phase 2
HY-141876 PRT543 / Phase 1

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P10238 MYBMIM Inducer 99.96% Unkown
HY-115881 SR-1114 Degrader 99.04% Unkown
HY-108634S Apafant-d8 / Unkown
HY-182681 AV-9606-129 Inhibitor / Unkown
HY-RS08869 MYB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174578 Human MYB mRNA / Unkown
HY-RS18120 Myb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24594 Myb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Myb NCBI NCBI:4602